Overview

NCI Definition: A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma. [1]

Low grade gliomas most frequently harbor alterations in IDH1, PIK3CA, TP53, NOTCH1, and ATRX [2].

Most Commonly Altered Genes in Low Grade Glioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, PIK3CA Mutation, and NOTCH1 Mutation are the most common alterations in low grade glioma [2].

Top Alterations in Low Grade Glioma

Significant Genes in Low Grade Glioma

ARAF +

BRAF +

CRKL +

EGFR +

ERBB2 +

HRAS +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

NF1 +

NRAS +

RAF1 +

SRC +

Disease Details

Synonyms
Low-Grade Glioma
Parent(s)
Glioma
Children
WHO Grade II Glioma, Low-Grade Glioma, NOS, Angiocentric Glioma, and Low Grade Astrocytic Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.