Overview

NCI Definition: A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma. [1]

Low grade gliomas most frequently harbor alterations in IDH1, CIC, BRAF, TP53, and NOTCH1 [2].

Most Commonly Altered Genes in Low Grade Glioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in low grade glioma [2].

Top Alterations in Low Grade Glioma

Significant Genes in Low Grade Glioma

ARAF +

BRAF +

CRKL +

EGFR +

ERBB2 +

FGFR1 +

FGFR2 +

FGFR3 +

HRAS +

IDH1 +

IDH2 +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MYB +

MYBL1 +

NF1 +

NF2 +

NRAS +

PTPN1 +

RAF1 +

SOS1 +

SRC +

Disease Details

Synonyms
Circumscribed low grade glioma, Low-Grade Glioma
Parent(s)
Glioma
Children
Ganglioglioma, Low-Grade Glioma, NOS, Low Grade Astrocytic Tumor, Pleomorphic Xanthoastrocytoma, WHO Grade II Glioma, and Angiocentric Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.