NCI Definition: A primary or metastatic malignant neoplasm involving the brain or spinal cord. Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic site. [1]

Malignant central nervous system neoplasms most frequently harbor alterations in TP53, KMT2D, TTYH1, BLM, and SH2B3 [2].

Most Commonly Altered Genes in Malignant Central Nervous System Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in malignant central nervous system neoplasm [2].

Top Alterations in Malignant Central Nervous System Neoplasm

Significant Genes in Malignant Central Nervous System Neoplasm

H3F3A +


Disease Details

Cancer of the CNS, Central Nervous System Cancer, Cancer of the Central Nervous System, Malignant Tumor of the Central Nervous System, Malignant CNS Tumor
Malignant Nervous System Neoplasm
Glioma, Central Nervous System Leukemia, Malignant Leptomeningeal Neoplasm, Central Nervous System Lymphoma, Central Nervous System Embryonal Neoplasm, Malignant Intracranial Neoplasm, Malignant Spinal Cord Neoplasm, Grade III Meningioma, Malignant Glioma, Malignant Central Nervous System Germ Cell Tumor, and Central Nervous System Sarcoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.