NCI Definition: A primary or metastatic malignant neoplasm involving the brain or spinal cord. Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic site. [1]

Malignant central nervous system neoplasms most frequently harbor alterations in TP53, IDH1, CDKN2A, PTEN, and CDKN2B [2].

Most Commonly Altered Genes in Malignant Central Nervous System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in malignant central nervous system neoplasm [2].

Top Alterations in Malignant Central Nervous System Neoplasm

Significant Genes in Malignant Central Nervous System Neoplasm



H3F3A +

MDM2 +

MDM4 +



ROS1 +



TET2 +

Disease Details

Malignant Tumor of the Central Nervous System, Malignant CNS Tumor, Cancer of the CNS, Central Nervous System Cancer, Cancer of the Central Nervous System
Malignant Nervous System Neoplasm
Malignant Neoplasm of the Meninges, Malignant Central Nervous System Germ Cell Tumor, Malignant Glioma, Central Nervous System Lymphoma, Central Nervous System Leukemia, Glioma, Malignant Intracranial Neoplasm, Malignant Spinal Cord Neoplasm, Central Nervous System Sarcoma, and Central Nervous System Embryonal Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.