Associated Genetic Biomarkers

Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the brain or spinal cord. Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic site. [1]

Significant Genes in Malignant Central Nervous System Neoplasm

ALK +

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

H3F3A +

MCPH1 +

MDM2 +

MDM4 +

MRE11A +

NBN +

PALB2 +

PPM1D +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RET +

ROS1 +

SLX4 +

SMARCA4 +

SMARCB1 +

TET2 +

Disease Details

Synonyms
Cancer of the Central Nervous System, Malignant Tumor of the Central Nervous System, Malignant CNS Tumor, Central Nervous System Cancer, Cancer of the CNS
Parent(s)
Malignant Nervous System Neoplasm
Children
Malignant Neoplasm of the Meninges, Central Nervous System Lymphoma, Central Nervous System Sarcoma, Malignant Central Nervous System Germ Cell Tumor, Malignant Spinal Cord Neoplasm, Malignant Intracranial Neoplasm, Central Nervous System Leukemia, Central Nervous System Embryonal Neoplasm, Malignant Glioma, and Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.