Associated Genetic Biomarkers

Overview

NCI Definition: A non-small cell lung carcinoma without evidence of squamous differentiation. [1]

Non-squamous non-small cell lung carcinomas most frequently harbor alterations in TP53, KRAS, EGFR, STK11, and CDKN2A [2].

Most Commonly Altered Genes in Non-Squamous Non-Small Cell Lung Carcinoma

TP53 Mutation, KRAS Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Exon 2 Mutation are the most common alterations in non-squamous non-small cell lung carcinoma [2].

Top Alterations in Non-Squamous Non-Small Cell Lung Carcinoma

Significant Genes in Non-Squamous Non-Small Cell Lung Carcinoma

ALK +

BRAF +

EGFR +

ERBB2 +

KEAP1 +

KRAS +

NFE2L2 +

RET +

ROS1 +

Disease Details

Synonyms
non-squamous non-small cell lung cancer, lung non-squamous non-small cell carcinoma
Parent(s)
Non-Small Cell Lung Carcinoma
Children
Lung Adenocarcinoma, Adenosquamous Lung Carcinoma, Large Cell Lung Carcinoma, Poorly Differentiated Non-Small Cell Lung Cancer, Lung Sarcomatoid Carcinoma, and Ciliated Muconodular Papillary Tumor of the Lung

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.