Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma which arises from the exocrine pancreas. Ductal adenocarcinoma and its variants are the most common types of pancreatic adenocarcinoma. [1]

Pancreatic adenocarcinomas most frequently harbor alterations in KRAS, TP53, CDKN2A, SMAD4, and CDKN2B [2].

Most Commonly Altered Genes in Pancreatic Adenocarcinoma

KRAS Mutation (somatic), KRAS Mutation (germline), KRAS Mutation, KRAS Codon 12 Missense, and TP53 Mutation are the most common alterations in pancreatic adenocarcinoma [2].

Top Alterations in Pancreatic Adenocarcinoma

Biomarker-Directed Therapies

Significant Genes in Pancreatic Adenocarcinoma

ALK +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

DVL1 +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

HDAC1 +

HDAC2 +

LRP5 +

LRP6 +

MCPH1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTAP +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS1 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RNF43 +

RSPO1 +

SLX4 +

STAG2 +

STK11 +

UGT1A1 +

WNT1 +

XRCC1 +

Disease Details

Synonyms
Adenocarcinoma - pancreas, Adenocarcinoma of Pancreas, Adenocarcinoma of the Pancreas, Pancreas Adenocarcinoma
Parent(s)
Pancreatic Carcinoma
Children
Mixed Ductal-Neuroendocrine Carcinoma of the Pancreas, Pancreatic Intraductal Papillary-colloid Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Acinar Cell Carcinoma, and Pancreatic Cystadenocarcinoma
OncoTree Name
Pancreatic Adenocarcinoma
OncoTree Code
PAAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.