Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the exocrine pancreas. The overwhelming majority of pancreatic carcinomas are adenocarcinomas. [1]

Pancreatic carcinomas most frequently harbor alterations in KRAS, TP53, CDKN2A, SMAD4, and CDKN2B [2].

Most Commonly Altered Genes in Pancreatic Carcinoma

KRAS Mutation (somatic), KRAS Mutation (germline), KRAS Mutation, KRAS Codon 12 Missense, and TP53 Mutation are the most common alterations in pancreatic carcinoma [2].

Top Alterations in Pancreatic Carcinoma

Significant Genes in Pancreatic Carcinoma

ABL1 +

ABL2 +

ACVR1B +

AKT1 +

AKT2 +

AKT3 +

ALK +

APC +

ARAF +

ASXL1 +

ATM +

ATR +

ATRX +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

C11ORF30 +

CDK12 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CRKL +

CYLD +

DDR2 +

DICER1 +

DNMT3A +

DVL1 +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FLT1 +

FLT3 +

FLT4 +

FRK +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

HDAC1 +

HDAC2 +

HGF +

HRAS +

IDH1 +

IRS2 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MAPK11 +

MDM2 +

MDM4 +

MED12 +

MET +

MGMT +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MTOR +

MUTYH +

MYC +

NBN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NPM1 +

NRAS +

NSD1 +

NTRK1 +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTCH1 +

PTEN +

PTPN11 +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RICTOR +

RNF43 +

RPTOR +

RSPO1 +

RUNX1 +

SETD2 +

SLX4 +

SMARCA4 +

SOX9 +

SRC +

STAG2 +

STK11 +

TAF1 +

TBX3 +

TEK +

TET2 +

TP53 +

TRNAK2 +

TSC1 +

TSC2 +

VEGFA +

VEGFB +

VEGFC +

WNT1 +

XPO1 +

XRCC1 +

Disease Details

Synonyms
Pancreatic cancer (excluding Islets), NOS, exocrine cancer, Pancreas Carcinoma, Exocrine Pancreas Carcinoma, Cancer of the Pancreas, Pancreatic Cancer, Carcinoma of the Pancreas, Pancreatic cancer (not Islets), Carcinoma of Pancreas, Pancreas Cancer, Cancer of Pancreas
Parent(s)
Malignant Exocrine Pancreatic Neoplasm
Children
Pancreatic Adenosquamous Carcinoma and Pancreatic Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.