Overview

NCI Definition: A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma occurring in children and young adults. Histologically it is characterized by a biphasic pattern with compacted bipolar cells associated with Rosenthal fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline droplets. (WHO) [1]

Pilocytic astrocytomas most frequently harbor alterations in BRAF, KIAA1549, NF1, FGFR1, and CIC [2].

Most Commonly Altered Genes in Pilocytic Astrocytoma

BRAF Fusion, KIAA1549-BRAF Fusion, BRAF-KIAA1549 Fusion, KIAA1549 Fusion, and BRAF Mutation are the most common alterations in pilocytic astrocytoma [2].

Top Alterations in Pilocytic Astrocytoma

Biomarker-Directed Therapies

Significant Genes in Pilocytic Astrocytoma

ARAF +

BRAF +

CRKL +

FGFR1 +

FGFR2 +

FGFR3 +

HRAS +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MYB +

MYBL1 +

NF1 +

NF2 +

NRAS +

PTPN1 +

RAF1 +

SOS1 +

SRC +

Disease Details

Synonyms
Brain atrorcytoma pilocytic, Grade I Astrocytic Tumor, Grade I Astrocytoma, ASTROCYTOMA, PILOCYTIC, BENIGN, Astrocytoma, Benign, Pilocytic Astrocytoma WHO grade I, Brain astrocytoma pilocytic, Grade I Astrocytic Neoplasm
Parent(s)
Low Grade Astrocytic Tumor
Children
Childhood Pilocytic Astrocytoma
OncoTree Name
Pilocytic Astrocytoma
OncoTree Code
PAST

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.