Associated Genetic Biomarkers

Overview

NCI Definition: A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis. [1]

Small cell lung carcinomas most frequently harbor alterations in TP53, RB1, KMT2D, PTEN, and CREBBP [2].

Most Commonly Altered Genes in Small Cell Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in small cell lung carcinoma [2].

Top Alterations in Small Cell Lung Carcinoma

Biomarker-Directed Therapies

Significant Genes in Small Cell Lung Carcinoma

AKT1 +

AKT2 +

AKT3 +

ATM +

ATR +

ATRX +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CDKN2A +

CHEK1 +

CHEK2 +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

HDAC1 +

HDAC2 +

HRAS +

KIT +

KRAS +

MCPH1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

MYC +

MYCL +

MYCN +

NBN +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD52 +

RAD54L +

RECQL4 +

RICTOR +

RPA1 +

SLX4 +

STAG2 +

STK11 +

TP53 +

VEGFA +

VEGFB +

WRN +

XRCC1 +

Disease Details

Synonyms
Small Cell Neuroendocrine Carcinoma of the Lung, Small Cell Lung Cancer, Lung Small Cell Neuroendocrine Carcinoma, Oat Cell Carcinoma of the Lung, Small Cell Carcinoma of the Lung, Oat Cell Carcinoma of Lung, Small Cell Neuroendocrine Carcinoma of Lung, Oat Cell Lung Carcinoma, Small Cell Carcinoma of Lung, SCLC, Lung Oat Cell Carcinoma
Parent(s)
Small Cell Carcinoma
Children
Combined Small Cell Lung Carcinoma and Occult Small Cell Lung Carcinoma
OncoTree Name
Small Cell Lung Cancer
OncoTree Code
SCLC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.