Overview

Location [1]
9p24.1
Pathway
JAK/STAT signaling
Synonyms [1]
JTK10

JAK2 (Janus kinase 2) encodes for tyrosine-protein kinase JAK2, a protein tyrosine kinase involved in cytokine receptor signaling. Mutations in JAK2 have been identified in ALL and other hematologic malignancies.

Significance of JAK2 in Diseases

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Myelodysplastic Syndromes +

Essential Thrombocythemia +

Malignant Solid Tumor +

Polycythemia Vera +

Mantle Cell Lymphoma +

Mixed Phenotype Acute Leukemia +

Multiple Myeloma +

Peripheral T-Cell Lymphoma +

Primary Myelofibrosis +

B-Cell Lymphoblastic Lymphoma +

Chronic Lymphocytic Leukemia +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

Lymphoproliferative Disorder +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myelofibrosis +

Myelofibrosis Transformation In Essential Thrombocythemia +

Myeloid Neoplasm +

Non-Hodgkin Lymphoma +

Plasma Cell Leukemia +

Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase +

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma +

Secondary Acute Myeloid Leukemia +

Splenic Marginal Zone Lymphoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.