Overview

Location [1]
17p12
Pathway
MAP kinase signaling
Synonyms [1]
SAPKK-1, SAPKK1, SERK1, MAPKK4, JNKK, SKK1, MKK4, MEK4, JNKK1, PRKMK4, SEK1

Mitogen-activated protein kinase kinase 4 (MAP2K4) is a gene that encodes a protein that is a member of the MAP kinase family. The protein functions in the signaling of multiple cellular processes including cellular proliferation, differentiation, transcription regulation, and development. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as breast cancer, intestinal cancer, and testicular cancer.

Significance of MAP2K4 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Low Grade Glioma +

Ovarian Carcinoma +

Thyroid Gland Carcinoma +

Acute Myeloid Leukemia +

Astrocytic Tumor +

Breast Carcinoma +

Cholangiocarcinoma +

Chronic Myelomonocytic Leukemia +

Cutaneous Melanoma +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Gangliocytoma +

Ganglioglioma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Malignant Peripheral Nerve Sheath Tumor +

Multiple Myeloma +

Myelodysplastic Syndromes +

Neuroblastoma +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.