Location [1]
MAP kinase signaling
Protein [2]
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms [1]

Mitogen-activated protein kinase kinase 4 (MAP2K4) is a gene that encodes a protein that is a member of the MAP kinase family. The protein functions in the signaling of multiple cellular processes including cellular proliferation, differentiation, transcription regulation, and development. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as breast cancer, intestinal cancer, and testicular cancer.

MAP2K4 is altered in 1.67% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, pancreatic adenocarcinoma, and leiomyosarcoma having the greatest prevalence of alterations [3].

MAP2K4 GENIE Cases - Top Diseases

The most common alterations in MAP2K4 are MAP2K4 Mutation (1.38%), MAP2K4 Loss (0.53%), MAP2K4 Amplification (0.17%), MAP2K4 S184L (0.05%), and MAP2K4 R134W (0.03%) [3].

MAP2K4 GENIE Cases - Top Alterations

Significance of MAP2K4 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Ovarian Carcinoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Gastric Carcinoma +

Breast Carcinoma +

Soft Tissue Sarcoma +

Endometrial Carcinoma +

Pancreatic Carcinoma +

Pancreatic Adenocarcinoma +

Cutaneous Melanoma +

Cholangiocarcinoma +

Esophageal Carcinoma +

Squamous Cell Lung Carcinoma +

Renal Cell Carcinoma +

Embryonal Rhabdomyosarcoma +

Hepatocellular Carcinoma +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Multiple Myeloma +

Neurofibromatosis Type 1 +

Poorly Differentiated Thyroid Gland Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.