Location [1]
MAP kinase signaling
Protein [2]
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms [1]

Mitogen-activated protein kinase kinase 4 (MAP2K4) is a gene that encodes a protein that is a member of the MAP kinase family. The protein functions in the signaling of multiple cellular processes including cellular proliferation, differentiation, transcription regulation, and development. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as breast cancer, intestinal cancer, and testicular cancer.

MAP2K4 is altered in 1.97% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, invasive breast carcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

MAP2K4 GENIE Cases - Top Diseases

The most common alterations in MAP2K4 are MAP2K4 Mutation (1.04%), MAP2K4 Loss (0.49%), MAP2K4 Amplification (0.17%), MAP2K4 R134W (0.04%), and MAP2K4 S184L (0.04%) [3].

MAP2K4 GENIE Cases - Top Alterations

Significance of MAP2K4 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Ovarian Carcinoma +

Glioma +

Low Grade Glioma +

Thyroid Gland Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Gastric Carcinoma +

Endometrial Carcinoma +

Breast Carcinoma +

Cutaneous Melanoma +

Soft Tissue Sarcoma +

Pancreatic Carcinoma +

Pancreatic Adenocarcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Squamous Cell Lung Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Diffuse Glioma +

Astrocytic Tumor +

Esophageal Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Cholangiocarcinoma +

Pilocytic Astrocytoma +

Hepatocellular Carcinoma +

Neuroblastoma +

Multiple Myeloma +

Renal Cell Carcinoma +

Myelodysplastic Syndromes +

Acute Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Gangliocytoma +

Ganglioglioma +

Low-Grade Neuroepithelial Tumor, NOS +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Pilomyxoid Astrocytoma +

Rhabdoid Tumor +

Schwannoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.