Biomarkers /
MAP2K4
Overview
Mitogen-activated protein kinase kinase 4 (MAP2K4) is a gene that encodes a protein that is a member of the MAP kinase family. The protein functions in the signaling of multiple cellular processes including cellular proliferation, differentiation, transcription regulation, and development. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as breast cancer, intestinal cancer, and testicular cancer.
Clinical Trials
Significance of MAP2K4 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.