Overview

Location [1]
22q11.22
Pathway
MAP kinase signaling
Protein [2]
Mitogen-activated protein kinase 1
Synonyms [1]
p42-MAPK, P42MAPK, p40, ERT1, ERK-2, p41, ERK, PRKM2, MAPK2, p41mapk, ERK2, PRKM1, p38

Mitogen-activated protein kinase 1 (MAPK1) is a gene that encodes a protein that belongs to the MAP kinase family. The protein functions in several cell signaling processes such as proliferation, differentiation, transcriptional regulation, and cellular development. Missense, nonsense, and silent mutations are observed in cancers such as cervical cancer, endometrial cancer, and skin cancer.

MAPK1 is altered in 0.75% of all cancers with lung adenocarcinoma, bladder urothelial carcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

MAPK1 GENIE Cases - Top Diseases

The most common alterations in MAPK1 are MAPK1 Mutation (0.51%), MAPK1 Amplification (0.26%), MAPK1 A7dup (0.12%), MAPK1 Loss (0.07%), and MAPK1 E322K (0.07%) [3].

MAPK1 GENIE Cases - Top Alterations

Significance of MAPK1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Glioma +

Ovarian Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Endometrial Carcinoma +

Soft Tissue Sarcoma +

Cutaneous Melanoma +

Squamous Cell Lung Carcinoma +

Breast Carcinoma +

Cholangiocarcinoma +

Embryonal Rhabdomyosarcoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Multiple Myeloma +

Neurofibromatosis Type 1 +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.