SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) is a gene that encodes a protein that functions in the removal of suppressive chromatin structures so that transcription may occur. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as bone cancer, central nervous system cancer, and intestinal cancer.
Modified: July 1, 2015
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