Overview

Location [1]
11p13
Pathway
Beta-Catenin/WNT signaling
Synonyms [1]
AWT1, GUD, WT33, WAGR, WIT-2, NPHS4

Wilms tumor 1 (WT1) is a gene that encodes a transcription factor that contains four zinc finger motifs and a proline/glutamine-rich DNA binding region at opposite termini. Fusions, missense mutations, nonsense mutations, silent mutations and frameshift deletions are observed in cancers such as acute lymphoblastic leukemia, chronic myeloid leukemia, kidney cancer, lung cancer, and skin cancer.

Significance of WT1 in Diseases

Acute Myeloid Leukemia +

Fallopian Tube Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Acute Biphenotypic Leukemia +

Acute Erythroid Leukemia +

Acute Lymphoblastic Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Undifferentiated Leukemia +

Chronic Myeloid Leukemia +

Desmoplastic Small Round Cell Tumor +

Endometrial Carcinoma +

Hodgkin Lymphoma +

Juvenile Myelomonocytic Leukemia +

Malignant Pleural Mesothelioma +

Mesothelioma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myeloid Neoplasm +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Non-Small Cell Lung Carcinoma +

Secondary Acute Myeloid Leukemia +

Soft Tissue Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.