Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Gene Location [1]
MAP kinase signaling

HRAS Mutation is present in 0.77% of AACR GENIE cases, with bladder urothelial carcinoma, lung adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma, and infiltrating renal pelvis and ureter urothelial carcinoma having the greatest prevalence [4].

Top Disease Cases with HRAS Mutation

Significance of HRAS Mutation in Diseases

Malignant Solid Tumor +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Melanoma +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Thyroid Gland Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Glioma +

Low Grade Glioma +

Acute Lymphoblastic Leukemia +

Histiocytic And Dendritic Cell Neoplasm +

Multiple Myeloma +

Pancreatic Ductal Adenocarcinoma +

Thyroid Gland Follicular Carcinoma +

Embryonal Rhabdomyosarcoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Thymic Carcinoma +

Urothelial Carcinoma +

Thyroid Gland Papillary Carcinoma +

Squamous Cell Carcinoma +

Cutaneous Melanoma +

Mucosal Melanoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Neuroblastoma +

Prostate Carcinoma +

Cancer +

Soft Tissue Sarcoma +

Breast Carcinoma +

Colorectal Adenocarcinoma +

Gastric Carcinoma +

Diffuse Glioma +

Renal Cell Carcinoma +

Astrocytic Tumor +

Hepatocellular Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Lymphoma +

Cholangiocarcinoma +

Chronic Myeloid Leukemia +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Ganglioglioma +

Histiocytosis +

Low Grade Ovarian Serous Adenocarcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Mantle Cell Lymphoma +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Peripheral T-Cell Lymphoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Rhabdoid Tumor +

Schwannoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.