Associated Diseases


Gene Location [1]
Variant Type

Biomarker-Directed Therapies

Significance of TNFRSF8 Expression in Diseases

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Hodgkin Lymphoma +

Anaplastic Large Cell Lymphoma +

Peripheral T-Cell Lymphoma +

Mycosis Fungoides +

Classical Hodgkin Lymphoma +

Peripheral T-Cell Lymphoma, Not Otherwise Specified +

Angioimmunoblastic T-Cell Lymphoma +

Enteropathy-Associated T-Cell Lymphoma +

Lymphoma +

Non-Hodgkin Lymphoma +

Sezary Syndrome +

Adult T-Cell Leukemia/Lymphoma +

Diffuse Large B-Cell Lymphoma +

Hepatosplenic T-Cell Lymphoma +

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Aggressive Non-Hodgkin Lymphoma +

Anaplastic Large Cell Lymphoma, ALK-Negative +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Follicular Lymphoma +

Follicular T-Cell Lymphoma +

Nasal Type Extranodal NK/T-Cell Lymphoma +

Primary Cutaneous Anaplastic Large Cell Lymphoma +

Aggressive Systemic Mastocytosis +

Anaplastic Large Cell Lymphoma, ALK-Positive +

B-Cell Non-Hodgkin Lymphoma +

Germ Cell Tumor +

Hematopoietic And Lymphoid System Neoplasm +

Lymphomatoid Papulosis +

Lymphomatous Adult T-Cell Leukemia/Lymphoma +

Malignant Mesothelioma +

Malignant Solid Tumor +

Mast Cell Leukemia +

Nodal Peripheral T-Cell Lymphoma With TFH Phenotype +

Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

Primary Cutaneous Follicle Center Lymphoma +

Primary Cutaneous Gamma-Delta T-Cell Lymphoma +

Subcutaneous Panniculitis-Like T-Cell Lymphoma +

T-Cell Non-Hodgkin Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.