Associated Genetic Biomarkers

Overview

NCI Definition: A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. [1]

Gastric carcinomas most frequently harbor alterations in TP53, ARID1A, CDH1, KRAS, and ERBB2 [2].

Most Commonly Altered Genes in Gastric Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, ARID1A Mutation, and CDH1 Mutation are the most common alterations in gastric carcinoma [2].

Top Alterations in Gastric Carcinoma

Biomarker-Directed Therapies

Significant Genes in Gastric Carcinoma

ABL1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHEK1 +

CHEK2 +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT4 +

FRK +

HDAC1 +

HDAC2 +

HRAS +

KDR +

KIT +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K3 +

MAP2K4 +

MAP2K5 +

MAP2K6 +

MAP2K7 +

MAPK1 +

MAPK11 +

MAPK3 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3CB +

PMS1 +

PMS2 +

POLD1 +

POLD2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RICTOR +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TEK +

TNFRSF10B +

TP53 +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

XRCC1 +

Disease Details

Synonyms
Cancer of Stomach, Gastric Cancer, Carcinoma of Stomach, Carcinoma of the Stomach, Cancer of the Stomach, Gastric cancer, NOS, Stomach Carcinoma, Stomach Cancer
Parent(s)
Malignant Gastric Neoplasm
Children
Gastric Cardia Carcinoma, Undifferentiated Gastric Carcinoma, Gastric Pylorus Carcinoma, Gastric Fundus Carcinoma, Gastric Adenocarcinoma, Gastric Neuroendocrine Carcinoma, Gastric Squamous Cell Carcinoma, Gastric Adenosquamous Carcinoma, and Gastric Body Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.