Associated Genetic Biomarkers

Overview

NCI Definition: A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. [1]

Biomarker-Directed Therapies

Significant Genes in Gastric Carcinoma

ABL1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BACH1 +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHEK1 +

CHEK2 +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT4 +

FRK +

HDAC1 +

HDAC2 +

HRAS +

IDH1 +

IDH2 +

KDR +

KIT +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K3 +

MAP2K4 +

MAP2K5 +

MAP2K6 +

MAP2K7 +

MAPK1 +

MAPK11 +

MAPK3 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3CB +

PMS1 +

PMS2 +

POLD1 +

POLD2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RICTOR +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TEK +

TNFRSF10B +

TP53 +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

XRCC1 +

Disease Details

Synonyms
Carcinoma of the Stomach, Gastric Cancer, Stomach Cancer, Gastric cancer, NOS, Cancer of Stomach, Cancer of the Stomach, Stomach Carcinoma, Carcinoma of Stomach
Parent(s)
Malignant Gastric Neoplasm
Children
Gastric Fundus Carcinoma, Gastric Adenocarcinoma, Gastric Pylorus Carcinoma, Gastric Squamous Cell Carcinoma, Undifferentiated Gastric Carcinoma, Gastric Adenosquamous Carcinoma, Gastric Neuroendocrine Carcinoma, Gastric Cardia Carcinoma, and Gastric Body Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.