Associated Genetic Biomarkers

Overview

NCI Definition: A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. [1]

Gastric carcinomas most frequently harbor alterations in TP53, ARID1A, CDH1, KRAS, and ERBB2 [2].

Most Commonly Altered Genes in Gastric Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in gastric carcinoma [2].

Top Alterations in Gastric Carcinoma

Biomarker-Directed Therapies

Significant Genes in Gastric Carcinoma

ABL1 +

ALK +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHEK1 +

CHEK2 +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT4 +

FRK +

HDAC1 +

HDAC2 +

KDR +

KIT +

KRAS +

MAPK11 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PMS1 +

PMS2 +

POLD1 +

POLD2 +

POLE +

PPP2R1A +

PPP2R2A +

PTCH1 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RICTOR +

SLX4 +

SMO +

STAG2 +

STK11 +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

XRCC1 +

Disease Details

Synonyms
Cancer of the Stomach, Cancer of Stomach, Gastric cancer, NOS, Stomach Cancer, Gastric Cancer, Carcinoma of the Stomach, Carcinoma of Stomach, Stomach Carcinoma
Parent(s)
Malignant Gastric Neoplasm
Children
Gastric Adenosquamous Carcinoma, Gastric Fundus Carcinoma, Undifferentiated Gastric Carcinoma, Gastric Adenocarcinoma, Gastric Small Cell Neuroendocrine Carcinoma, Gastric Pylorus Carcinoma, Gastric Cardia Carcinoma, Gastric Squamous Cell Carcinoma, and Gastric Body Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.