Associated Genetic Biomarkers

Overview

NCI Definition: A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. [1]

Gastric carcinomas most frequently harbor alterations in TP53, ARID1A, CDH1, KRAS, and ERBB2 [2].

Most Commonly Altered Genes in Gastric Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, ARID1A Mutation, and CDH1 Mutation are the most common alterations in gastric carcinoma [2].

Top Alterations in Gastric Carcinoma

Biomarker-Directed Therapies

Significant Genes in Gastric Carcinoma

ABL1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHEK1 +

CHEK2 +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT4 +

FRK +

HDAC1 +

HDAC2 +

HRAS +

KDR +

KIT +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K3 +

MAP2K4 +

MAP2K5 +

MAP2K6 +

MAP2K7 +

MAPK1 +

MAPK11 +

MAPK3 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3CB +

PMS1 +

PMS2 +

POLD1 +

POLD2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RICTOR +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TEK +

TNFRSF10B +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

XRCC1 +

Disease Details

Synonyms
Carcinoma of the Stomach, Stomach Carcinoma, Gastric Cancer, Stomach Cancer, Cancer of Stomach, Gastric cancer, NOS, Cancer of the Stomach, Carcinoma of Stomach
Parent(s)
Malignant Gastric Neoplasm
Children
Gastric Neuroendocrine Carcinoma, Gastric Adenosquamous Carcinoma, Gastric Pylorus Carcinoma, Gastric Cardia Carcinoma, Gastric Body Carcinoma, Gastric Adenocarcinoma, Undifferentiated Gastric Carcinoma, Gastric Squamous Cell Carcinoma, and Gastric Fundus Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.