Associated Genetic Biomarkers

Overview

NCI Definition: A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas. [1]

Lymphomas most frequently harbor alterations in KMT2D, CREBBP, TP53, BCL2, and TET2 [2].

Most Commonly Altered Genes in Lymphoma

KMT2D Mutation, CREBBP Mutation, TP53 Mutation, BCL2 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in lymphoma [2].

Top Alterations in Lymphoma

Significant Genes in Lymphoma

ABL1 +

ABL2 +

ACVR1B +

AFF1 +

AKT1 +

ALK +

APC +

APH1A +

ASXL1 +

ATM +

ATR +

BCR +

BIRC3 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

CBFB +

CCND1 +

CCND2 +

CCND3 +

CDK12 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CSF1R +

CYLD +

DDR2 +

DEK +

DICER1 +

DLL4 +

DNMT3A +

EGFR +

ELL +

EPHA2 +

ERBB2 +

ERBB3 +

EZH2 +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

FLT4 +

FYN +

GATA3 +

GNA11 +

GNAQ +

HGF +

IDH1 +

IDH2 +

IGH +

JAG1 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2A +

KMT2D +

KRAS +

LCK +

LYN +

MAF +

MAGI2 +

MAML1 +

MAP3K1 +

MDM2 +

MDM4 +

MECOM +

MED12 +

MET +

MGMT +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MSH2 +

MSH6 +

MTAP +

MTOR +

MYC +

MYH11 +

NCSTN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PBX1 +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

POLD1 +

POLE +

PTCH1 +

PTEN +

PTPN11 +

RAF1 +

RB1 +

RET +

ROS1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SETD2 +

SF3B1 +

SMARCA4 +

SMO +

SOX9 +

SRC +

STAG2 +

TAF1 +

TBX3 +

TCF3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

WHSC1 +

XPO1 +

YES1 +

Disease Details

Synonyms
Lymphoma, NOS, Malignant Lymphoma, LYMPHOMA, MALIGNANT, Lymphoma (Hodgkin and Non-Hodgkin), Lymphomatous, Lymphoma (Hodgkin's and Non-Hodgkin's)
Parent(s)
Lymphocytic Neoplasm
Children
Precursor T-Cell Lymphoblastic Lymphoma/Leukemia, Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Adult Lymphoma, Virus-Related Lymphoma, Central Nervous System Lymphoma, B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma, Breast Lymphoma, Childhood Lymphoma, Digestive System Lymphoma, Precursor Lymphoid Neoplasm, Small Intestinal Lymphoma, and Methotrexate-Associated Lymphoproliferative Disorder

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.