Associated Genetic Biomarkers

Overview

NCI Definition: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001) [1]

Significant Genes in Multiple Myeloma

ABL1 +

AFF1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

ASXL1 +

ATM +

ATR +

BARD1 +

BCL2 +

BCL6 +

BCR +

BIRC3 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CALR +

CBFB +

CCND1 +

CCND2 +

CCND3 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2C +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

DDR2 +

DEK +

EGFR +

ELL +

EPHA2 +

ERBB2 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLCN +

FLT1 +

FLT3 +

FLT4 +

FYN +

GNA11 +

GNAQ +

HRAS +

IDH1 +

IDH2 +

IGH +

IKZF1 +

JAK2 +

KDR +

KIT +

KMT2A +

KRAS +

LCK +

LYN +

MAF +

MAFB +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MECOM +

MET +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MPL +

MRE11A +

MTOR +

MYC +

MYH11 +

NBN +

NF1 +

NF2 +

NPM1 +

NRAS +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PALB2 +

PBX1 +

PDGFRA +

PDGFRB +

PIK3CA +

PIK3R1 +

POLD1 +

POLE +

PTCH1 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAF1 +

RET +

RHEB +

ROS1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SLX4 +

SMO +

SRC +

SRSF2 +

STK11 +

TCF3 +

TP53 +

TSC1 +

TSC2 +

VHL +

WHSC1 +

YES1 +

Disease Details

Synonyms
MYELOMA, PLASMA CELL, MALIGNANT, myelomatosis, Myeloma, NOS, Myeloma, Plasma Cell Myeloma, Kahler disease
Parent(s)
Plasma Cell Neoplasm
Children
Non-Secretory Plasma Cell Myeloma, Indolent Plasma Cell Myeloma, Smoldering Plasma Cell Myeloma, Refractory Plasma Cell Myeloma, Osteosclerotic Plasma Cell Myeloma, and Refractory Plasma Cell Neoplasm
OncoTree Name
Plasma Cell Myeloma
OncoTree Code
PCM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.