Diseases /
Non-Hodgkin Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. [1]
Non-hodgkin lymphomas most frequently harbor alterations in KMT2D, CREBBP, TP53, BCL2, and TNFRSF14 [2].
CREBBP Mutation, KMT2D Mutation, TP53 Mutation, KMT2fs, and TP53 c.217-c.1178 Missense are the most common alterations in non-hodgkin lymphoma [2].
Clinical Trials
Significant Genes in Non-Hodgkin Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.