Associated Genetic Biomarkers

Overview

NCI Definition: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. [1]

Non-hodgkin lymphomas most frequently harbor alterations in KMT2D, CREBBP, TP53, TNFAIP3, and SOCS1 [2].

Most Commonly Altered Genes in Non-Hodgkin Lymphoma

KMT2D Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Mutation are the most common alterations in non-hodgkin lymphoma [2].

Top Alterations in Non-Hodgkin Lymphoma

Significant Genes in Non-Hodgkin Lymphoma

ABL1 +

AFF1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

ASXL1 +

ATM +

ATR +

ATRX +

BARD1 +

BCL2 +

BCL6 +

BCR +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CBFA2T3 +

CBFB +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHEK1 +

CHEK2 +

CREBBP +

CRKL +

CSF1R +

DEK +

EGFR +

ELL +

EPHA2 +

ERBB2 +

ERG +

ETV6 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

FLT4 +

FUS +

FYN +

GLIS2 +

HDAC1 +

HDAC2 +

HOXA9 +

HRAS +

IKZF1 +

IRS2 +

JAK2 +

KAT6A +

KDM5A +

KDR +

KIT +

KMT2A +

KRAS +

LCK +

LYN +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MDM4 +

MECOM +

MET +

MLF1 +

MLH1 +

MLH3 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MUTYH +

MYC +

MYH11 +

NBN +

NF1 +

NPM1 +

NRAS +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

NUP98 +

PALB2 +

PARP1 +

PARP2 +

PBX1 +

PDGFRA +

PDGFRB +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTCH1 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RICTOR +

RNF43 +

ROS1 +

RPN1 +

RPTOR +

RUNX1 +

RUNX1T1 +

SLX4 +

SMARCA4 +

SMARCB1 +

SRC +

STAG2 +

STK11 +

TCF3 +

TP53 +

TSC1 +

TSC2 +

WT1 +

XRCC1 +

YES1 +

Disease Details

Synonyms
Non-Hodgkins, Non-Hodgkin's Lymphoma (NHL), Non-Hodgkin's Lymphoma, NHL, Non-Hodgkin lymphoma, NOS, NHL, NOS
Parent(s)
Lymphoma
Children
Lymphoblastic Lymphoma, B-Cell Non-Hodgkin Lymphoma, Transformed Lymphoma, Non-Hodgkin Lymphoma by Clinical Course, Mediastinal Large B-Cell Lymphoma, T-Cell Non-Hodgkin Lymphoma, and Testicular Lymphoma
OncoTree Name
Non-Hodgkin Lymphoma
OncoTree Code
NHL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.