Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from malignant squamous bronchial epithelial cells and characterized by the presence of keratinization and/or intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma. [1]

Squamous cell lung carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, KMT2D, and NFE2L2 [2].

Most Commonly Altered Genes in Squamous Cell Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in squamous cell lung carcinoma [2].

Top Alterations in Squamous Cell Lung Carcinoma

Significant Genes in Squamous Cell Lung Carcinoma

AKT1 +

AKT2 +

AKT3 +

ARAF +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CDK12 +

CDK4 +

CDK6 +

CHEK1 +

CHEK2 +

CRKL +

DVL1 +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

HDAC1 +

HDAC2 +

HGF +

HRAS +

IRS2 +

KEAP1 +

KIT +

KRAS +

LRP5 +

LRP6 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MUTYH +

NBN +

NF1 +

NFE2L2 +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PIK3CA +

PIK3CB +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RET +

RICTOR +

RNF43 +

RPTOR +

RSPO1 +

SLX4 +

SRC +

STAG2 +

STK11 +

TSC1 +

TSC2 +

WNT1 +

XRCC1 +

Disease Details

Synonyms
Squamous Cell Carcinoma of the Lung, Squamous Cell Lung Cancer, Epidermoid Cell Lung Carcinoma, Epidermoid Cell Carcinoma of Lung, Epidermoid Cell Carcinoma of the Lung, Squamous cell lung carcinoma, Squamous Cell Carcinoma of Lung, Lung Squamous Cell Carcinoma
Parent(s)
Squamous Cell Carcinoma
Children
Occult Squamous Cell Lung Carcinoma
OncoTree Name
Lung Squamous Cell Carcinoma
OncoTree Code
LUSC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.