Biomarkers /
FGFR1
Overview
FGFR1 (fibroblast growth factor receptor type 1) encodes the fibroblast growth factor receptor type 1 protein, a receptor tyrosine kinase. FGFR1 and other FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by amplification, point mutation, or translocation (PMID: 20094046). Amplification or activation of FGFR1 has been reported in many cancers, including oral squamous cell carcinoma (PMID: 16807070), breast cancer (PMID: 20179196), esophageal squamous cell carcinoma (PMID: 12147242), ovarian cancer (PMID: 17699850), bladder cancer (PMID: 11389083), prostate cancer (PMID: 14614009), and lung cancer, predominantly in the squamous subtype (PMID: 21666749; PMID: 17982442; PMID: 21160078).
Clinical Trials
Significance of FGFR1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.