Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
4p16.3
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
HSFGFR3EX, CD333, CEK2, JTK4, ACH

The fibroblast growth factor receptor 3 (FGFR3) gene encodes one member of the FGF receptor tyrosine kinase family, which includes four kinases: FGFR1, FGFR2, FGFR3, and FGFR4. FGFRs are involved in downstream signaling via the MAP kinase, JAK/STAT, and PI3K/AKT pathways. FGFR3 gene aberrations have been reported in urothelial, breast, head and neck, lung, brain, gastric, pancreatic, colorectal, kidney, endometrial, ovarian, and cervical cancers and are known to be highly prevalent in bladder cancers.

Biomarker-Directed Therapies

Significance of FGFR3 in Diseases

Urothelial Carcinoma +

Bladder Carcinoma +

Multiple Myeloma +

Malignant Solid Tumor +

Acute Lymphoblastic Leukemia +

Plasma Cell Leukemia +

Acute Myeloid Leukemia +

Breast Carcinoma +

Cholangiocarcinoma +

Myelodysplastic Syndromes +

Non-Small Cell Lung Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Cancer +

Non-Hodgkin Lymphoma +

Chronic Lymphocytic Leukemia +

Chronic Myeloid Leukemia +

Smoldering Plasma Cell Myeloma +

Adenocarcinoma Of The Gastroesophageal Junction +

Chronic Myelomonocytic Leukemia +

Endometrial Carcinoma +

Gastric Carcinoma +

Squamous Cell Lung Carcinoma +

Transitional Cell Carcinoma +

Bladder Urothelial Carcinoma +

Colorectal Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Hodgkin Lymphoma +

Lymphoblastic Lymphoma +

Lymphoma +

Mixed Phenotype Acute Leukemia +

Myeloproliferative Neoplasm +

Non-Muscle Invasive Bladder Carcinoma +

Sarcoma +

Anaplastic Astrocytoma +

Anaplastic Oligodendroglioma +

Aplastic Anemia +

Astrocytic Tumor +

B-Cell Lymphoblastic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Diffuse Glioma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Esophageal Squamous Cell Carcinoma +

Extrahepatic Cholangiocarcinoma +

Gallbladder Carcinoma +

Gangliocytoma +

Ganglioglioma +

Gastrointestinal Stromal Tumor +

Glioblastoma +

Glioma +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Hypopharyngeal Squamous Cell Carcinoma +

Infiltrating Renal Pelvis And Ureter Urothelial Carcinoma +

Intrahepatic Cholangiocarcinoma +

Invasive Breast Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Low Grade Glioma +

Low-Grade Neuroepithelial Tumor, NOS +

Lung Carcinoma +

Lymphocytic Neoplasm +

Malignant Glioma +

Malignant Uterine Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Melanoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Myelodysplastic/Myeloproliferative Neoplasm +

Myelofibrosis +

Myeloid Neoplasm +

Myeloma +

Neuronal And Mixed Neuronal-Glial Tumors +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Plasmacytoma +

Prolymphocytic Leukemia +

Renal Pelvis Urothelial Carcinoma +

Secondary Acute Myeloid Leukemia +

Small Cell Lung Carcinoma +

Small Lymphocytic Lymphoma +

Soft Tissue Sarcoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Triple-Hit Lymphoma +

Ureter Urothelial Carcinoma +

Urethral Urothelial Carcinoma +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.