Associated Genetic Biomarkers
Associated Diseases

Overview

Biomarker-Directed Therapies

Significance of HER2 in Diseases

Breast Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Colorectal Carcinoma +

Gastric Carcinoma +

Malignant Salivary Gland Neoplasm +

Malignant Esophageal Neoplasm +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Breast Adenocarcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Invasive Breast Carcinoma +

Melanoma +

Pancreatic Carcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Fallopian Tube Carcinoma +

Renal Cell Carcinoma +

Primary Peritoneal Carcinoma +

Prostate Carcinoma +

Small Cell Lung Carcinoma +

Esophageal Carcinoma +

Bladder Carcinoma +

Cervical Carcinoma +

Hepatocellular Carcinoma +

Head And Neck Carcinoma +

Pancreatic Adenocarcinoma +

Ductal Carcinoma In Situ +

Esophageal Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Lymphoma +

Soft Tissue Sarcoma +

Breast Invasive Ductal Carcinoma +

Colorectal Adenocarcinoma +

Glioblastoma +

Mesothelioma +

Pancreatic Ductal Adenocarcinoma +

Cancer +

Cholangiocarcinoma +

Inflammatory Breast Carcinoma +

Prostate Adenocarcinoma +

Sarcoma +

Nasopharyngeal Carcinoma +

Non-Hodgkin Lymphoma +

Acute Myeloid Leukemia +

Esophageal Squamous Cell Carcinoma +

Esophagogastric Carcinoma +

Gallbladder Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Merkel Cell Carcinoma +

Peritoneal Mesothelioma +

Biliary Tract Carcinoma +

Carcinoma +

Chronic Lymphocytic Leukemia +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Multiple Myeloma +

Bile Duct Carcinoma +

Breast Lobular Carcinoma In Situ +

Classical Hodgkin Lymphoma +

Colon Carcinoma +

Hematopoietic And Lymphoid Malignancy +

High Grade Fallopian Tube Serous Adenocarcinoma +

Lung Adenocarcinoma +

Malignant Pleural Mesothelioma +

Malignant Uterine Neoplasm +

Mantle Cell Lymphoma +

Myelodysplastic Syndromes +

Non-Squamous Non-Small Cell Lung Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Pleural Mesothelioma +

Thymic Carcinoma +

Acute Lymphoblastic Leukemia +

Adenoid Cystic Carcinoma +

Anal Canal Squamous Cell Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Breast Invasive Lobular Carcinoma +

Central Nervous System Neoplasm +

Cervical Squamous Cell Carcinoma +

Cutaneous Melanoma +

Fallopian Tube Endometrioid Adenocarcinoma +

Gastrointestinal Stromal Tumor +

Hypopharyngeal Squamous Cell Carcinoma +

Intrahepatic Cholangiocarcinoma +

Kidney Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Leukemia +

Lobular Breast Carcinoma +

Lung Carcinoma +

Neuroendocrine Carcinoma +

Primary Peritoneal Serous Adenocarcinoma +

Skin Squamous Cell Carcinoma +

Small Intestinal Adenocarcinoma +

Thymoma +

Thyroid Gland Carcinoma +

Uterine Corpus Carcinosarcoma +

Adnexal Carcinoma +

Aggressive Systemic Mastocytosis +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Anal Squamous Cell Carcinoma +

Anaplastic Astrocytoma +

B-Cell Neoplasm +

Basal Cell Carcinoma +

Benign Breast Neoplasm +

Biliary Tract Neoplasm +

Bladder Urothelial Carcinoma +

Brain Metastasis +

Bronchogenic Carcinoma +

Cervical Carcinosarcoma +

Chondrosarcoma +

Chordoma +

Desmoid-Type Fibromatosis +

Diffuse Gastric Adenocarcinoma +

Digestive System Carcinoma +

Endometrial Adenocarcinoma +

Endometrial Endometrioid Adenocarcinoma +

Endometrial Mixed Adenocarcinoma +

Endometrial Serous Adenocarcinoma +

Ependymoma +

Ewing Sarcoma +

Extrahepatic Cholangiocarcinoma +

Fallopian Tube Clear Cell Adenocarcinoma +

Germ Cell Tumor +

Glioma +

Gliosarcoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Hypopharyngeal Carcinoma +

Kaposi Sarcoma +

Laryngeal Carcinoma +

Leiomyosarcoma +

Liposarcoma +

Low Grade Glioma +

Malignant Bone Marrow Neoplasm +

Malignant Glioma +

Malignant Mixed Mesodermal (Mullerian) Tumor +

Malignant Ovarian Clear Cell Tumor +

Malignant Thyroid Gland Neoplasm +

Mast Cell Leukemia +

Medullary Breast Carcinoma +

Medulloblastoma +

Mixed Lobular And Ductal Breast Carcinoma +

Myeloid Neoplasm +

Myxofibrosarcoma +

NUT Midline Carcinoma Of The Head And Neck +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Carcinoma +

Osteosarcoma +

Ovarian Endometrioid Adenocarcinoma +

Ovarian Endometrioid Tumor +

Ovarian Epithelial Tumor +

Pecoma +

Pancreatic Neuroendocrine Neoplasm +

Papillary Renal Cell Carcinoma +

Penile Carcinoma +

Primary Cutaneous T Cell Non-Hodgkin Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Primary Peritoneal Carcinosarcoma +

Prostate Undifferentiated Carcinoma +

Renal Pelvis And Ureter Carcinoma +

Salivary Carcinoma, NOS +

Salivary Duct Carcinoma +

Salivary Gland Acinic Cell Carcinoma +

Salivary Gland Adenocarcinoma +

Salivary Gland Carcinoma +

Salivary Gland Carcinoma Ex Pleomorphic Adenoma +

Salivary Gland Mucoepidermoid Carcinoma +

Salivary Gland Small Cell Carcinoma +

Salivary Gland Squamous Cell Carcinoma +

Small Intestinal Carcinoma +

Squamous Cell Carcinoma Of The Penis +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

T-Cell And NK-Cell Neoplasm +

Tenosynovial Giant Cell Tumor +

Tenosynovial Giant Cell Tumor, Diffuse Type +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Ureter Urothelial Carcinoma +

Urethral Carcinoma +

Uterine Carcinosarcoma +

Uveal Melanoma +

Vulvar Carcinoma +

Well-Differentiated Thyroid Gland Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.