Overview

Location [1]
15q22.31
Pathway
MAP kinase signaling
Protein [2]
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms [1]
MKK1, PRKMK1, MAPKK1, MEK1, CFC3

MAP2K1 (mitogen-activated protein kinase kinase 1, also known as MEK1) encodes for the protein dual specificity mitogen-activated protein kinase kinase 1. As part of the MAP kinase pathway, MAP2K1 is involved in many cellular processes, including cell proliferation, differentiation, and transcriptional regulation.

 

MAP2K1 is altered in 0.86% of all cancers with cutaneous melanoma, colon adenocarcinoma, lung adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

MAP2K1 GENIE Cases - Top Diseases

The most common alterations in MAP2K1 are MAP2K1 Mutation (0.98%), MAP2K1 E203K (0.09%), MAP2K1 K57N (0.07%), MAP2K1 Amplification (0.04%), and MAP2K1 Q56P (0.03%) [3].

MAP2K1 GENIE Cases - Top Alterations

Significance of MAP2K1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Ovarian Carcinoma +

Cutaneous Melanoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Cancer +

Squamous Cell Lung Carcinoma +

Renal Cell Carcinoma +

Breast Carcinoma +

Acute Myeloid Leukemia +

Cholangiocarcinoma +

Embryonal Rhabdomyosarcoma +

Hepatocellular Carcinoma +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Multiple Myeloma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myeloid Neoplasm +

Neurofibromatosis Type 1 +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Soft Tissue Sarcoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.