Overview

Location [1]
15q22.31
Pathway
MAP kinase signaling
Synonyms [1]
MAPKK1, MKK1, MEK1, CFC3, MEL, PRKMK1

MAP2K1 (mitogen-activated protein kinase kinase 1, also known as MEK1) encodes for the protein dual specificity mitogen-activated protein kinase kinase 1. As part of the MAP kinase pathway, MAP2K1 is involved in many cellular processes, including cell proliferation, differentiation, and transcriptional regulation.

 

Significance of MAP2K1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Acute Myeloid Leukemia +

Colorectal Carcinoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Low Grade Glioma +

Ovarian Carcinoma +

Thyroid Gland Carcinoma +

Astrocytic Tumor +

Breast Carcinoma +

Cancer +

Cholangiocarcinoma +

Chronic Myelomonocytic Leukemia +

Cutaneous Melanoma +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Gangliocytoma +

Ganglioglioma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Malignant Peripheral Nerve Sheath Tumor +

Mucosal Melanoma +

Multiple Myeloma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Neuroblastoma +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.