Overview

Location [1]
3q26.2
Protein [2]
MDS1 and EVI1 complex locus protein
Synonyms [1]
AML1-EVI-1, MDS1, RUSAT2, EVI1, PRDM3, KMT8E, MDS1-EVI1

MDS1 and EVI1 complex locus (MECOM) is a gene that encodes a protein that functions as a transcriptional regulator and oncoprotein. The protein may also have roles in hematopoiesis, apoptosis, development, cell differentiation, and cell proliferation. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

MECOM is altered in 3.15% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, cutaneous melanoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

MECOM GENIE Cases - Top Diseases

The most common alterations in MECOM are MECOM Mutation (1.17%), MECOM Amplification (0.17%), MECOM G614Efs*30 (0.05%), MECOM E24K (0.02%), and MECOM P276L (0.01%) [3].

MECOM GENIE Cases - Top Alterations

Significance of MECOM in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myelomonocytic Leukemia +

Chronic Myeloid Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Acute Biphenotypic Leukemia +

Myelofibrosis +

Chronic Lymphocytic Leukemia +

Primary Myelofibrosis +

Burkitt Lymphoma +

Mantle Cell Lymphoma +

Myeloproliferative Neoplasm +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Anaplastic Large Cell Lymphoma +

Secondary Acute Myeloid Leukemia +

Acute Leukemia +

Follicular Lymphoma +

Marginal Zone Lymphoma +

Myelofibrosis Transformation In Essential Thrombocythemia +

Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase +

Refractory Anemia With Excess Blasts +

Therapy-Related Acute Myeloid Leukemia +

Juvenile Myelomonocytic Leukemia +

Lymphoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Prolymphocytic Leukemia +

Secondary Myelofibrosis +

Therapy-Related Myelodysplastic Syndrome +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndrome With Excess Blasts-2 +

Secondary Myelodysplastic Syndrome +

Small Lymphocytic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Acute Undifferentiated Leukemia +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Plasma Cell Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Blastic Plasmacytoid Dendritic Cell Neoplasm +

Refractory Anemia +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Peripheral T-Cell Lymphoma +

T-Cell Non-Hodgkin Lymphoma +

Malignant Solid Tumor +

Acute Bilineal Leukemia +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Acute Promyelocytic Leukemia +

Burkitt Leukemia +

Chronic Myelomonocytic Leukemia-1 +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Neoplasm +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Refractory Anemia With Excess Blasts-1 +

Small Lymphocytic Leukemia +

Leukemia +

Acute Erythroid Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Acute Megakaryoblastic Leukemia +

Adult Acute Lymphoblastic Leukemia +

Adult T-Cell Leukemia/Lymphoma +

Aggressive Non-Hodgkin Lymphoma +

Aplastic Anemia +

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +

B-Cell Prolymphocytic Leukemia +

Chronic Myelomonocytic Leukemia-0 +

Chronic Myelomonocytic Leukemia-2 +

Desmoplastic Small Round Cell Tumor +

Ewing Sarcoma +

Hematopoietic And Lymphoid Malignancy +

Histiocytic And Dendritic Cell Neoplasm +

Indolent Non-Hodgkin Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloid Sarcoma +

NK-Cell Lymphoma, Unclassifiable +

Neuroblastoma +

Plasma Cell Neoplasm +

Polycythemia Vera +

Refractory Anemia With Ring Sideroblasts +

Rhabdomyosarcoma +

Richter Syndrome +

Systemic Mastocytosis +

T-Cell Prolymphocytic Leukemia +

T-Cell And NK-Cell Neoplasm +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myeloid Neoplasm +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.