Overview

Location [1]
3q26.2
Protein [2]
MDS1 and EVI1 complex locus protein
Synonyms [1]
AML1-EVI-1, KMT8E, MDS1, RUSAT2, PRDM3, MDS1-EVI1, EVI1

MDS1 and EVI1 complex locus (MECOM) is a gene that encodes a protein that functions as a transcriptional regulator and oncoprotein. The protein may also have roles in hematopoiesis, apoptosis, development, cell differentiation, and cell proliferation. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

MECOM is altered in 3.15% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, cutaneous melanoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

MECOM GENIE Cases - Top Diseases

The most common alterations in MECOM are MECOM Mutation (1.17%), MECOM Amplification (0.17%), MECOM G614Efs*30 (0.05%), MECOM E24K (0.02%), and MECOM P276L (0.01%) [3].

MECOM GENIE Cases - Top Alterations

Significance of MECOM in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Acute Biphenotypic Leukemia +

Chronic Lymphocytic Leukemia +

Myelofibrosis +

Myeloproliferative Neoplasm +

Burkitt Lymphoma +

Mantle Cell Lymphoma +

Primary Myelofibrosis +

Acute Leukemia +

Anaplastic Large Cell Lymphoma +

Follicular Lymphoma +

Marginal Zone Lymphoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Lymphoma +

Juvenile Myelomonocytic Leukemia +

Prolymphocytic Leukemia +

Lymphoplasmacytic Lymphoma +

Lymphoblastic Lymphoma +

Refractory Anemia With Excess Blasts +

Secondary Myelodysplastic Syndrome +

Secondary Myelofibrosis +

Small Lymphocytic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Mixed Phenotype Acute Leukemia +

Plasma Cell Leukemia +

Refractory Anemia With Excess Blasts-2 +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Blastic Plasmacytoid Dendritic Cell Neoplasm +

Mature T-Cell And NK-Cell Neoplasm +

Myelofibrosis Transformation In Essential Thrombocythemia +

Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Therapy-Related Myelodysplastic Syndrome +

Peripheral T-Cell Lymphoma +

T-Cell Non-Hodgkin Lymphoma +

Malignant Solid Tumor +

Acute Bilineal Leukemia +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Acute Promyelocytic Leukemia +

Acute Undifferentiated Leukemia +

Burkitt Leukemia +

Chronic Myelomonocytic Leukemia-1 +

Hematopoietic And Lymphoid Malignancy +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Refractory Anemia +

Small Lymphocytic Leukemia +

T-Cell Acute Lymphoblastic Leukemia +

Acute Erythroid Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Acute Megakaryoblastic Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Adult Acute Lymphoblastic Leukemia +

Adult T-Cell Leukemia/Lymphoma +

Aplastic Anemia +

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +

B-Cell Acute Lymphoblastic Leukemia +

B-Cell Prolymphocytic Leukemia +

Chronic Myelomonocytic Leukemia-0 +

Desmoplastic Small Round Cell Tumor +

Ewing Sarcoma +

Histiocytic And Dendritic Cell Neoplasm +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloid Sarcoma +

Myeloma +

Neuroblastoma +

Plasma Cell Neoplasm +

Polycythemia Vera +

Refractory Anemia With Excess Blasts-1 +

Refractory Anemia With Ring Sideroblasts +

Rhabdomyosarcoma +

Richter Syndrome +

Systemic Mastocytosis +

T-Cell Prolymphocytic Leukemia +

T-Cell And NK-Cell Neoplasm +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myeloid Neoplasm +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.