Overview

Location [1]
3q26.2
Synonyms [1]
MDS1, EVI1, AML1-EVI-1, PRDM3, RUSAT2, KMT8E, MDS1-EVI1

MDS1 and EVI1 complex locus (MECOM) is a gene that encodes a protein that functions as a transcriptional regulator and oncoprotein. The protein may also have roles in hematopoiesis, apoptosis, development, cell differentiation, and cell proliferation. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Significance of MECOM in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myelomonocytic Leukemia +

Chronic Myeloid Leukemia +

Primary Myelofibrosis +

Hodgkin Lymphoma +

Multiple Myeloma +

Myelofibrosis +

Non-Hodgkin Lymphoma +

Acute Biphenotypic Leukemia +

Myelofibrosis Transformation In Essential Thrombocythemia +

Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase +

Chronic Lymphocytic Leukemia +

Burkitt Lymphoma +

Mantle Cell Lymphoma +

Myeloproliferative Neoplasm +

Acute Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Anaplastic Large Cell Lymphoma +

Refractory Anemia With Excess Blasts +

Follicular Lymphoma +

Marginal Zone Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Secondary Acute Myeloid Leukemia +

Secondary Myelofibrosis +

Therapy-Related Acute Myeloid Leukemia +

Juvenile Myelomonocytic Leukemia +

Mixed Phenotype Acute Leukemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Lymphoma +

Prolymphocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Small Lymphocytic Lymphoma +

Acute Undifferentiated Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Plasma Cell Leukemia +

Secondary Myelodysplastic Syndrome +

B-Cell Acute Lymphoblastic Leukemia +

Refractory Anemia +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Acute Bilineal Leukemia +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Acute Promyelocytic Leukemia +

Blastic Plasmacytoid Dendritic Cell Neoplasm +

Burkitt Leukemia +

Chronic Myelomonocytic Leukemia-1 +

Malignant Solid Tumor +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Neoplasm +

Myelodysplastic Syndrome With Excess Blasts-1 +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Peripheral T-Cell Lymphoma +

Small Lymphocytic Leukemia +

T-Cell Non-Hodgkin Lymphoma +

Acute Erythroid Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Acute Megakaryoblastic Leukemia +

Adult Acute Lymphoblastic Leukemia +

Adult T-Cell Leukemia/Lymphoma +

Aggressive Non-Hodgkin Lymphoma +

Aplastic Anemia +

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +

B-Cell Prolymphocytic Leukemia +

Chronic Myelomonocytic Leukemia-0 +

Chronic Myelomonocytic Leukemia-2 +

Desmoplastic Small Round Cell Tumor +

Essential Thrombocythemia +

Ewing Sarcoma +

Hematopoietic And Lymphoid Malignancy +

Histiocytic And Dendritic Cell Neoplasm +

Indolent Non-Hodgkin Lymphoma +

Leukemia +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloid Neoplasm +

NK-Cell Lymphoma, Unclassifiable +

Neuroblastoma +

Overt Primary Myelofibrosis +

Plasma Cell Neoplasm +

Polycythemia Vera +

Refractory Anemia With Ring Sideroblasts +

Rhabdomyosarcoma +

Richter Syndrome +

Systemic Mastocytosis +

T-Cell Prolymphocytic Leukemia +

T-Cell And NK-Cell Neoplasm +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myeloid Neoplasm +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.