Associated Genetic Biomarkers

Overview

Gene Location [1]
1p13.2
Pathway
MAP kinase signaling
Gene
NRAS

NRAS Mutation is present in 2.43% of AACR GENIE cases, with cutaneous melanoma, melanoma, colon adenocarcinoma, acute myeloid leukemia, and lung adenocarcinoma having the greatest prevalence [4].

Top Disease Cases with NRAS Mutation

Significance of NRAS Mutation in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Colorectal Carcinoma +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Non-Hodgkin Lymphoma +

Acute Lymphoblastic Leukemia +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Multiple Myeloma +

Poorly Differentiated Thyroid Gland Carcinoma +

Cutaneous Melanoma +

Colorectal Adenocarcinoma +

Cancer +

Glioma +

Breast Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Myelodysplastic Syndrome With Excess Blasts-2 +

Neuroblastoma +

Pancreatic Ductal Adenocarcinoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Thyroid Gland Follicular Carcinoma +

Embryonal Rhabdomyosarcoma +

Thyroid Gland Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Thyroid Gland Papillary Carcinoma +

Myeloid Neoplasm +

Colon Carcinoma +

Lymphoma +

Cholangiocarcinoma +

Endometrial Carcinoma +

Soft Tissue Sarcoma +

Bladder Carcinoma +

Sarcoma +

Esophageal Carcinoma +

Lung Carcinoma +

Squamous Cell Carcinoma +

Glioblastoma +

Pancreatic Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Anaplastic Astrocytoma +

Chronic Myeloid Leukemia +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Gastric Carcinoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Mantle Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Neurofibromatosis Type 1 +

Peripheral T-Cell Lymphoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Secondary Myelodysplastic Syndrome +

Small Cell Lung Carcinoma +

Therapy-Related Myelodysplastic Syndrome +

Thymic Carcinoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.