Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma that arises from and straddles the junction of the stomach and esophagus. The category of adenocarcinomas of the gastroesophageal junction also includes the majority of adenocarcinomas previously called gastric cardia adenocarcinomas. Squamous cell carcinomas that affect or cross the junction of the stomach and esophagus are classified as carcinomas of the distal esophagus. Adenocarcinoma of the gastroesophageal junction occurs more often in Caucasian middle aged and elderly males. Clinical signs and symptoms include dysphagia, abdominal pain, and weight loss. The prognosis depends on the completeness of the surgical resection, the number of lymph nodes involved by cancer, and the presence or absence of postoperative complications. The presence of TP53 mutations indicates worse prognosis. [1]

Adenocarcinoma of the gastroesophageal junctions most frequently harbor alterations in TP53, ERBB2, CDKN2A, KRAS, and ARID1A [2].

Most Commonly Altered Genes in Adenocarcinoma of the Gastroesophageal Junction

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in adenocarcinoma of the gastroesophageal junction [2].

Top Alterations in Adenocarcinoma of the Gastroesophageal Junction

Significant Genes in Adenocarcinoma of the Gastroesophageal Junction

ABL1 +

ALK +

APC +

ARID1A +

ATM +

ATR +

ATRX +

AXIN1 +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

CSNK1A1 +

CTNNA1 +

CTNNB1 +

DDR2 +

DVL1 +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GEN1 +

GSK3B +

HDAC1 +

HDAC2 +

KDR +

KIT +

KRAS +

LRP5 +

LRP6 +

MAPK11 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

MYC +

NBN +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTCH1 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RET +

SLX4 +

SMO +

STAG2 +

STK11 +

TEK +

TP53 +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

WISP3 +

WNT1 +

WT1 +

XRCC1 +

Disease Details

Synonyms
Adenocarcinoma of Cardioesophageal junction, Adenocarcinoma of the EG Junction, Adenocarcinoma of Gastroesophageal Junction, Adenocarcinoma of the Esophagogastric Junction, Adenocarcinoma - GEJ, Adenocarcinoma of the GE Junction, Adenocarcinoma of the Cardioesophageal junction, Gastroesophageal Junction Adenocarcinoma
Parent(s)
Esophagogastric Carcinoma
OncoTree Name
Adenocarcinoma of the Gastroesophageal Junction
OncoTree Code
GEJ

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.