Associated Genetic Biomarkers

Overview

Cancers most frequently harbor alterations in TP53, KRAS, PIK3CA, APC, and CDKN2A [2].

Most Commonly Altered Genes in Cancer

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in cancer [2].

Top Alterations in Cancer

Significant Genes in Cancer

ABL1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

APOBEC1 +

APOBEC2 +

APOBEC3A +

APOBEC3B +

APOBEC3C +

APOBEC3D +

APOBEC3F +

APOBEC3G +

APOBEC3H +

APOBEC4 +

ARID1A +

ATM +

ATR +

AXL +

BRAF +

BRCA1 +

BRCA2 +

C11ORF30 +

CCND1 +

CCND3 +

CDK4 +

CDK6 +

CDKN2A +

CRKL +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

FLT4 +

HRAS +

IDH1 +

IGH +

IRS2 +

KDR +

KIT +

KRAS +

MAGEA3 +

MAP2K1 +

MET +

MRE11A +

MTOR +

NBN +

NF1 +

NF2 +

NRAS +

PALB2 +

PDGFRA +

PDGFRB +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

POLD1 +

POLE +

PTEN +

RAD50 +

RET +

RHEB +

RICTOR +

RNF43 +

ROS1 +

RPTOR +

STK11 +

TP53 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Poorly Differentiated Malignant Neoplasm, Malignant Neoplasm
Parent(s)
Neoplasm
Children
Malignant Solid Tumor, Immunodeficiency-Related Malignant Neoplasm, Therapy-Related Malignant Neoplasm, Secondary Malignant Neoplasm, Cancer, NOS, Undifferentiated Malignant Neoplasm, Cell Type Cancer, Plasma Cell Neoplasm, Plasmacytoma, Histiocytic And Dendritic Cell Cancer, and Hematopoietic and Lymphoid Malignancy

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.