Associated Genetic Biomarkers

Overview

Cancers most frequently harbor alterations in TP53, KRAS, BRAF, PIK3CA, and CTNNB1 [2].

Most Commonly Altered Genes in Cancer

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in cancer [2].

Top Alterations in Cancer

Significant Genes in Cancer

ABL1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

ARID1A +

ATM +

ATR +

AXL +

BRAF +

BRCA1 +

BRCA2 +

C11ORF30 +

CCND1 +

CCND3 +

CDK4 +

CDK6 +

CDKN2A +

CRKL +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

FLT4 +

HRAS +

IDH1 +

IGH +

IRS2 +

KDR +

KIT +

KRAS +

MAGEA3 +

MAP2K1 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTOR +

NBN +

NF1 +

NF2 +

NRAS +

PALB2 +

PDGFRA +

PDGFRB +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

PTEN +

RAD50 +

RET +

RHEB +

RICTOR +

RNF43 +

ROS1 +

RPTOR +

STK11 +

TP53 +

TSC1 +

TSC2 +

Disease Details

Children
Plasma Cell Neoplasm, Cancer, NOS, Malignant Solid Tumor, Histiocytic And Dendritic Cell Cancer, Hematopoietic and Lymphoid Malignancy, Metastatic Malignant Neoplasm in the Brain, and Cell Type Cancer

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.