Associated Genetic Biomarkers

Overview

NCI Definition: The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) [1]

Glioblastomas most frequently harbor alterations in CDKN2A, PTEN, TP53, CDKN2B, and EGFR [2].

Most Commonly Altered Genes in Glioblastoma

CDKN2A Loss, TP53 Mutation, CDKN2B Loss, TP53 c.217-c.1178 Missense, and TP53 c.142-c.212 Missense are the most common alterations in glioblastoma [2].

Top Alterations in Glioblastoma

Significant Genes in Glioblastoma

ABL2 +

ACVR1B +

AKT1 +

AKT2 +

AKT3 +

ALK +

APC +

ASXL1 +

ATM +

ATR +

BLM +

BRAF +

BRCA1 +

BRCA2 +

CDK12 +

CDKN1A +

CDKN1B +

CDKN2A +

CDKN2B +

CDKN2C +

CHD4 +

CRKL +

CYLD +

DICER1 +

DNMT3A +

EGFR +

ERBB2 +

ERBB3 +

EZH2 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA3 +

H3F3A +

HGF +

IDH1 +

IDH2 +

IRS2 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

MAGI2 +

MAP3K1 +

MDM2 +

MED12 +

MET +

MGMT +

MSH2 +

MSH6 +

MTOR +

MYC +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

PDGFRA +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTCH1 +

PTEN +

PTPN11 +

RB1 +

RICTOR +

RNF43 +

RPTOR +

RUNX1 +

SETD2 +

SMARCA4 +

SOX9 +

STAG2 +

TAF1 +

TBX3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

XPO1 +

Disease Details

Synonyms
grade IV astrocytoma, GBM (Glioblastoma), Glioblastoma Multiforme, Spongioblastoma Multiforme, Grade IV Astrocytic Tumor, Grade IV Astrocytic Neoplasm, GBM
Parent(s)
High Grade Astrocytic Tumor
Children
Small Cell Glioblastoma, Glioblastoma, IDH- Wildtype, Conventional Glioblastoma Multiforme, Adult Glioblastoma, and Brain Glioblastoma
OncoTree Name
Glioblastoma
OncoTree Code
GB

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.