Associated Genetic Biomarkers

Overview

NCI Definition: The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) [1]

Significant Genes in Glioblastoma

ABL2 +

ACVR1B +

ALK +

APC +

ASXL1 +

ATM +

ATR +

ATRX +

BLM +

BRAF +

BRCA1 +

BRCA2 +

CDK12 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CDKN2B +

CDKN2C +

CHD4 +

CTDNEP1 +

CTNNB1 +

CYLD +

DDX3X +

DICER1 +

DNMT3A +

EGFR +

ERBB2 +

ERBB3 +

EZH2 +

FGF19 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA3 +

GLI2 +

H3F3A +

HGF +

IDH1 +

IDH2 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2C +

KMT2D +

KRAS +

LRP1B +

MAGI2 +

MAP3K1 +

MDM4 +

MED12 +

MET +

MSH2 +

MSH6 +

MYC +

MYCL +

MYCN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

OTX2 +

PDGFRA +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PPM1D +

PTCH1 +

PTEN +

PTPN11 +

PVT1 +

RB1 +

RELA +

RUNX1 +

SETD2 +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SOX9 +

STAG2 +

SUFU +

TAF1 +

TBX3 +

TERT +

TET2 +

TNFRSF10B +

TP53 +

XPO1 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
GBM, Glioblastoma WHO grade IV, Spongioblastoma Multiforme, GBM (Glioblastoma), Grade IV Astrocytic Neoplasm, Glioblastoma Multiforme, Glioblastoma, WHO grade IV, Grade IV Astrocytic Tumor, High-Grade Astrocytoma WHO Grade IV, grade IV astrocytoma
Parent(s)
High Grade Astrocytic Tumor
Children
Glioblastoma, IDH-Mutant, Small Cell Glioblastoma, Conventional Glioblastoma Multiforme, Brain Glioblastoma, Mesenchymal Glioblastoma, Adult Glioblastoma, Childhood Glioblastoma, Proneural Glioblastoma, and Glioblastoma, IDH-Wildtype
OncoTree Name
Glioblastoma
OncoTree Code
GB

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.