Associated Genetic Biomarkers

Overview

NCI Definition: A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands. [1]

Head and neck squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, NOTCH1, and KMT2D [2].

Most Commonly Altered Genes in Head and Neck Squamous Cell Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, PIK3CA Mutation, and CDKN2A Mutation are the most common alterations in head and neck squamous cell carcinoma [2].

Top Alterations in Head and Neck Squamous Cell Carcinoma

Significant Genes in Head and Neck Squamous Cell Carcinoma

AKT1 +

AKT2 +

AKT3 +

ARID1A +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

C11ORF30 +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CRKL +

DDR2 +

DVL1 +

EGFR +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

HDAC1 +

HDAC2 +

HRAS +

IRS2 +

KDR +

KIT +

KRAS +

LRP5 +

LRP6 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTAP +

MTOR +

MUTYH +

MYC +

NBN +

NOTCH1 +

NPM1 +

NRAS +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PIK3AP1 +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PIK3R5 +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RET +

RICTOR +

RNF43 +

RPTOR +

RSPO1 +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

WNT1 +

XRCC1 +

Disease Details

Synonyms
Squamous Cell Carcinoma of the Head and Neck, Head and neck squamous cell carcinoma, NOS, Head and neck squamous cell carcinoma (HNSCC), SCCHN, Squamous Cell Carcinoma of Head and Neck
Parent(s)
Squamous Cell Carcinoma
Children
Pharyngeal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma of Unknown Primary, Middle Ear Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma of the Head and Neck, Lacrimal Gland Squamous Cell Carcinoma, Salivary Gland Squamous Cell Carcinoma, Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, and Laryngeal Squamous Cell Carcinoma
OncoTree Name
Head and Neck Squamous Cell Carcinoma
OncoTree Code
HNSC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.