Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. [1]

Soft tissue sarcomas most frequently harbor alterations in TP53, RB1, CDKN2A, ATRX, and CDKN2B [2].

Most Commonly Altered Genes in Soft Tissue Sarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDKN2A Loss, and ATRX Mutation are the most common alterations in soft tissue sarcoma [2].

Top Alterations in Soft Tissue Sarcoma

Significant Genes in Soft Tissue Sarcoma

APH1A +

ARAF +

ARID1A +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CRKL +

DLL4 +

ERBB2 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

HDAC1 +

HDAC2 +

HRAS +

JAG1 +

KIT +

KRAS +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PIK3CA +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

SLX4 +

SMARCA4 +

SMARCB1 +

SRC +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Non-Rhabdomyosarcoma soft tissue sarcoma, NOS, soft tissue sarcoma, Sarcoma of the Soft Tissue, Connective Tissue Sarcoma, Sarcoma of Soft Tissue, Non-Rhabdo. soft tissue sarcoma
Parent(s)
Sarcoma
Children
Colorectal Sarcoma, Synovial Sarcoma, Uterine Sarcoma, Superior Vena Cava Angiosarcoma, Tracheal Sarcoma, Thyroid Gland Sarcoma, Bile Duct Sarcoma, Dendritic Cell Sarcoma, Small Intestinal Sarcoma, Testicular Sarcoma, Extraskeletal Ewing Sarcoma, Vaginal Sarcoma, Round Cell Sarcoma, Stromal Sarcoma, Undifferentiated Sarcoma, Retroperitoneal Sarcoma, Extraskeletal Osteosarcoma, Epithelioid Sarcoma, Clear Cell Sarcoma of Soft Tissue, Alveolar Soft Part Sarcoma, Prostate Sarcoma, Paranasal Sinus Sarcoma, Cervical Leiomyosarcoma, Vulvar Sarcoma, Laryngeal Sarcoma, Myxosarcoma, Cervical Sarcoma, Gastric Leiomyosarcoma, Desmoplastic Small Round Cell Tumor, Ovarian Sarcoma, Esophageal Sarcoma, Undifferentiated Pleomorphic Sarcoma, Pulmonary Vein Leiomyosarcoma, Gastric Liposarcoma, Kidney Sarcoma, Skin Sarcoma, Anal Sarcoma, Cardiac Sarcoma, Pulmonary Artery Leiomyosarcoma, Breast Sarcoma, Lung Sarcoma, Fallopian Tube Leiomyosarcoma, Mediastinal Sarcoma, Orbit Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Rhabdomyosarcoma, Intimal Sarcoma, Liver Sarcoma, Splenic Angiosarcoma, Soft Tissue Fibrosarcoma, Gallbladder Sarcoma, Central Nervous System Sarcoma, and Aortic Angiosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.