Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. [1]

Soft tissue sarcomas most frequently harbor alterations in TP53, RB1, CDKN2A, ATRX, and CDKN2B [2].

Most Commonly Altered Genes in Soft Tissue Sarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDKN2A Loss, and ATRX Mutation are the most common alterations in soft tissue sarcoma [2].

Top Alterations in Soft Tissue Sarcoma

Significant Genes in Soft Tissue Sarcoma

APH1A +

ARAF +

ARID1A +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CRKL +

DLL4 +

ERBB2 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

HDAC1 +

HDAC2 +

HRAS +

JAG1 +

KIT +

KRAS +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PIK3CA +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

SLX4 +

SMARCA4 +

SMARCB1 +

SRC +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Non-Rhabdo. soft tissue sarcoma, Non-Rhabdomyosarcoma soft tissue sarcoma, NOS, Sarcoma of the Soft Tissue, Sarcoma of Soft Tissue, Connective Tissue Sarcoma, soft tissue sarcoma, Soft tissue sarcoma (NOS)
Parent(s)
Sarcoma
Children
Stromal Sarcoma, Uterine Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Round Cell Sarcoma, Cervical Sarcoma, Myxosarcoma, Breast Sarcoma, Extraskeletal Osteosarcoma, Vulvar Sarcoma, Ovarian Sarcoma, Extraskeletal Ewing Sarcoma, Clear Cell Sarcoma of Soft Tissue, Epithelioid Sarcoma, Anal Sarcoma, Aortic Angiosarcoma, Prostate Sarcoma, Undifferentiated Pleomorphic Sarcoma, Skin Sarcoma, Soft Tissue Fibrosarcoma, Bile Duct Sarcoma, Desmoplastic Small Round Cell Tumor, Fallopian Tube Leiomyosarcoma, Dendritic Cell Sarcoma, Gastric Liposarcoma, Gallbladder Sarcoma, Superior Vena Cava Angiosarcoma, Pulmonary Vein Leiomyosarcoma, Splenic Angiosarcoma, Thyroid Gland Sarcoma, Retroperitoneal Sarcoma, Kidney Sarcoma, Synovial Sarcoma, Small Intestinal Sarcoma, Liver Sarcoma, Esophageal Sarcoma, Lung Sarcoma, Central Nervous System Sarcoma, Intimal Sarcoma, Orbit Sarcoma, Paranasal Sinus Sarcoma, Tracheal Sarcoma, Gastric Leiomyosarcoma, Colorectal Sarcoma, Rhabdomyosarcoma, Cardiac Sarcoma, Cervical Leiomyosarcoma, Mediastinal Sarcoma, Pulmonary Artery Leiomyosarcoma, Laryngeal Sarcoma, Vaginal Sarcoma, Alveolar Soft Part Sarcoma, Testicular Sarcoma, and Undifferentiated/Unclassified Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.