Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. [1]

Soft tissue sarcomas most frequently harbor alterations in TP53, EWSR1, CDKN2A, RB1, and ATRX [2].

Most Commonly Altered Genes in Soft Tissue Sarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in soft tissue sarcoma [2].

Top Alterations in Soft Tissue Sarcoma

Significant Genes in Soft Tissue Sarcoma

APH1A +

ARAF +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCNE1 +

CDK12 +

CHEK1 +

CHEK2 +

CRKL +

DLL4 +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

HDAC1 +

HDAC2 +

HRAS +

JAG1 +

KRAS +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PIK3CA +

PMS2 +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

SLX4 +

SRC +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Sarcoma of the Soft Tissue, Non-Rhabdo. soft tissue sarcoma, Sarcoma of Soft Tissue, Non-Rhabdomyosarcoma soft tissue sarcoma, NOS, soft tissue sarcoma, Connective Tissue Sarcoma
Parent(s)
Sarcoma
Children
Vulvar Sarcoma, Superior Vena Cava Angiosarcoma, Undifferentiated Pleomorphic Sarcoma, Intimal Sarcoma, Round Cell Sarcoma, Testicular Sarcoma, Skin Sarcoma, Liver Sarcoma, Bile Duct Sarcoma, Desmoplastic Small Round Cell Tumor, Gallbladder Sarcoma, Paranasal Sinus Sarcoma, Soft Tissue Fibrosarcoma, Kidney Sarcoma, Synovial Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Ovarian Sarcoma, Retroperitoneal Sarcoma, Vaginal Sarcoma, Pulmonary Artery Leiomyosarcoma, Epithelioid Sarcoma, Myxosarcoma, Extraskeletal Osteosarcoma, Anal Sarcoma, Alveolar Soft Part Sarcoma, Thyroid Sarcoma, Rhabdomyosarcoma, Splenic Angiosarcoma, Gastric Leiomyosarcoma, Mediastinal Sarcoma, Colorectal Sarcoma, Extraskeletal Ewing Sarcoma, Gastric Liposarcoma, Small Intestinal Sarcoma, Undifferentiated Sarcoma, Fallopian Tube Leiomyosarcoma, Dendritic Cell Sarcoma, Aortic Angiosarcoma, Central Nervous System Sarcoma, Orbit Sarcoma, Prostate Sarcoma, Stromal Sarcoma, Tracheal Sarcoma, Laryngeal Sarcoma, Cervical Sarcoma, Esophageal Sarcoma, Cardiac Sarcoma, Clear Cell Sarcoma of Soft Tissue, Uterine Sarcoma, Pulmonary Vein Leiomyosarcoma, Breast Sarcoma, and Cervical Leiomyosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.