Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. [1]

Significant Genes in Soft Tissue Sarcoma

AKT1 +

ALK +

APH1A +

ARAF +

ARID1A +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BCL2 +

BCL6 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

DDIT3 +

DLL4 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EWSR1 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

FOXO1 +

HDAC1 +

HDAC2 +

HRAS +

JAG1 +

KDM6A +

KDR +

KIT +

KMT2C +

KMT2D +

KRAS +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NR4A3 +

NRAS +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFB +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SRC +

SS18 +

SSBP1 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

STAG2 +

STK11 +

TFE3 +

TP53 +

TSC1 +

TSC2 +

VHL +

WT1 +

XRCC1 +

Disease Details

Synonyms
Non-Rhabdomyosarcoma soft tissue sarcoma, NOS, Sarcoma of Soft Tissue, soft tissue sarcoma, Non-Rhabdo. soft tissue sarcoma, Connective Tissue Sarcoma, Soft tissue sarcoma (NOS), PEDIATRIC Soft tissue sarcoma (NOS), Sarcoma of the Soft Tissue
Parent(s)
Sarcoma
Children
Vulvar Sarcoma, Paranasal Sinus Sarcoma, Extraskeletal Osteosarcoma, Epithelioid Sarcoma, Lung Sarcoma, Aortic Angiosarcoma, Orbit Sarcoma, Synovial Sarcoma, Digestive System Sarcoma, Pulmonary Artery Leiomyosarcoma, Mediastinal Sarcoma, Retroperitoneal Sarcoma, Clear Cell Sarcoma of Soft Tissue, Tracheal Sarcoma, Breast Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Kidney Sarcoma, Cervical Sarcoma, Stromal Sarcoma, Thyroid Gland Sarcoma, Bladder Sarcoma, Testicular Sarcoma, Skin Sarcoma, Prostate Sarcoma, Vaginal Sarcoma, Superior Vena Cava Angiosarcoma, Gastrointestinal Stromal Tumor, Ovarian Sarcoma, Central Nervous System Sarcoma, Soft Tissue Fibrosarcoma, Undifferentiated Pleomorphic Sarcoma, Pulmonary Vein Leiomyosarcoma, Desmoplastic Small Round Cell Tumor, Cardiac Sarcoma, Extraskeletal Ewing Sarcoma, Fallopian Tube Leiomyosarcoma, Cervical Leiomyosarcoma, Uterine Sarcoma, Bile Duct Sarcoma, Dendritic Cell Sarcoma, Intimal Sarcoma, Alveolar Soft Part Sarcoma, Rhabdomyosarcoma, Myxosarcoma, Round Cell Sarcoma, Splenic Angiosarcoma, Undifferentiated/Unclassified Sarcoma, and Laryngeal Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.