Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. [1]

Soft tissue sarcomas most frequently harbor alterations in KIT, TP53, CDKN2A, CDKN2B, and RB1 [2].

Most Commonly Altered Genes in Soft Tissue Sarcoma

KIT Mutation, KIT Exon 11 Mutation, KIT Deletion, KIT Exon 11 Deletion, and TP53 Mutation are the most common alterations in soft tissue sarcoma [2].

Top Alterations in Soft Tissue Sarcoma

Significant Genes in Soft Tissue Sarcoma

AKT1 +

ALK +

APH1A +

ARAF +

ARID1A +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

DLL4 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

HRAS +

JAG1 +

KDM6A +

KDR +

KIT +

KMT2C +

KMT2D +

KRAS +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

NRG1 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SRC +

SS18 +

SSBP1 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
soft tissue sarcoma, Sarcoma of the Soft Tissue, Non-Rhabdomyosarcoma soft tissue sarcoma, NOS, Soft tissue sarcoma (NOS), Sarcoma of Soft Tissue, Connective Tissue Sarcoma, Non-Rhabdo. soft tissue sarcoma
Parent(s)
Sarcoma
Children
Lung Sarcoma, Prostate Sarcoma, Extraskeletal Ewing Sarcoma, Alveolar Soft Part Sarcoma, Stromal Sarcoma, Intimal Sarcoma, Bladder Sarcoma, Laryngeal Sarcoma, Dendritic Cell Sarcoma, Kidney Sarcoma, Aortic Angiosarcoma, Thyroid Gland Sarcoma, Myxosarcoma, Gastrointestinal Stromal Tumor, Pulmonary Artery Leiomyosarcoma, Undifferentiated/Unclassified Sarcoma, Skin Sarcoma, Superior Vena Cava Angiosarcoma, Vulvar Sarcoma, Breast Sarcoma, Pulmonary Vein Leiomyosarcoma, Central Nervous System Sarcoma, Retroperitoneal Sarcoma, Mediastinal Sarcoma, Rhabdomyosarcoma, Cervical Leiomyosarcoma, Tracheal Sarcoma, Epithelioid Sarcoma, Synovial Sarcoma, Uterine Sarcoma, Vaginal Sarcoma, Clear Cell Sarcoma of Soft Tissue, Undifferentiated Pleomorphic Sarcoma, Splenic Angiosarcoma, Cervical Sarcoma, Paranasal Sinus Sarcoma, Extraskeletal Osteosarcoma, Desmoplastic Small Round Cell Tumor, Orbit Sarcoma, Digestive System Sarcoma, Ovarian Sarcoma, Round Cell Sarcoma, Cardiac Sarcoma, Bile Duct Sarcoma, Fallopian Tube Leiomyosarcoma, Soft Tissue Fibrosarcoma, Extraskeletal Myxoid Chondrosarcoma, and Testicular Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.