Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. [1]

Soft tissue sarcomas most frequently harbor alterations in KIT, TP53, CDKN2A, CDKN2B, and RB1 [2].

Most Commonly Altered Genes in Soft Tissue Sarcoma

KIT Mutation, KIT Exon 11 Mutation, KIT Deletion, KIT Exon 11 Deletion, and TP53 Mutation are the most common alterations in soft tissue sarcoma [2].

Top Alterations in Soft Tissue Sarcoma

Significant Genes in Soft Tissue Sarcoma

AKT1 +

ALK +

APH1A +

ARAF +

ARID1A +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BCL2 +

BCL6 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

DDIT3 +

DLL4 +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EWSR1 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

FOXO1 +

HDAC1 +

HDAC2 +

HRAS +

JAG1 +

KDM6A +

KDR +

KIT +

KMT2C +

KMT2D +

KRAS +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NR4A3 +

NRAS +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFB +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SRC +

SS18 +

SSBP1 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

STAG2 +

STK11 +

TFE3 +

TP53 +

TSC1 +

TSC2 +

VHL +

WT1 +

XRCC1 +

Disease Details

Synonyms
Soft tissue sarcoma (NOS), Non-Rhabdo. soft tissue sarcoma, soft tissue sarcoma, PEDIATRIC Soft tissue sarcoma (NOS), Connective Tissue Sarcoma, Non-Rhabdomyosarcoma soft tissue sarcoma, NOS, Sarcoma of Soft Tissue, Sarcoma of the Soft Tissue
Parent(s)
Sarcoma
Children
Testicular Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Stromal Sarcoma, Synovial Sarcoma, Aortic Angiosarcoma, Ovarian Sarcoma, Kidney Sarcoma, Extraskeletal Ewing Sarcoma, Round Cell Sarcoma, Orbit Sarcoma, Vulvar Sarcoma, Bile Duct Sarcoma, Gastrointestinal Stromal Tumor, Rhabdomyosarcoma, Pulmonary Artery Leiomyosarcoma, Skin Sarcoma, Retroperitoneal Sarcoma, Undifferentiated/Unclassified Sarcoma, Fallopian Tube Leiomyosarcoma, Desmoplastic Small Round Cell Tumor, Epithelioid Sarcoma, Digestive System Sarcoma, Mediastinal Sarcoma, Superior Vena Cava Angiosarcoma, Clear Cell Sarcoma of Soft Tissue, Pulmonary Vein Leiomyosarcoma, Uterine Sarcoma, Paranasal Sinus Sarcoma, Splenic Angiosarcoma, Cardiac Sarcoma, Soft Tissue Fibrosarcoma, Bladder Sarcoma, Cervical Leiomyosarcoma, Alveolar Soft Part Sarcoma, Extraskeletal Osteosarcoma, Central Nervous System Sarcoma, Prostate Sarcoma, Vaginal Sarcoma, Cervical Sarcoma, Breast Sarcoma, Thyroid Gland Sarcoma, Myxosarcoma, Dendritic Cell Sarcoma, Tracheal Sarcoma, Undifferentiated Pleomorphic Sarcoma, Intimal Sarcoma, Laryngeal Sarcoma, and Lung Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.