Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
7p11.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
NISBD2, ERBB, HER1, ERBB1, PIG61, mENA

EGFR (epidermal growth factor receptor, also known as ERBB1 and HER1) is a gene that encodes for the epidermal growth factor receptor protein. Missense mutations, deletions, and insertions are observed in cancers such as lung cancer and glioblastoma. Activating EGFR mutations increase the kinase activity of EGFR, leading to hyperactivation of downstream pro-survival signaling pathways (PMID: 15284455).

Biomarker-Directed Therapies

Significance of EGFR in Diseases

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Malignant Solid Tumor +

Glioblastoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Lung Adenocarcinoma +

Gastric Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Malignant Glioma +

Melanoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

Esophageal Carcinoma +

Hepatocellular Carcinoma +

Small Cell Lung Carcinoma +

Anaplastic Astrocytoma +

Chordoma +

Gastric Adenocarcinoma +

Glioma +

Gliosarcoma +

Head And Neck Carcinoma +

Lung Carcinoma +

Anaplastic Oligoastrocytoma +

Cancer +

Cervical Carcinoma +

Cholangiocarcinoma +

Colorectal Adenocarcinoma +

Diffuse Astrocytoma +

Diffuse Intrinsic Pontine Glioma +

Endometrial Carcinoma +

Esophageal Squamous Cell Carcinoma +

Malignant Central Nervous System Neoplasm +

Malignant Salivary Gland Neoplasm +

Medulloblastoma +

Multiple Myeloma +

Nasopharyngeal Carcinoma +

Ovarian Carcinoma +

Pancreatic Adenocarcinoma +

Sarcoma +

Anal Canal Squamous Cell Carcinoma +

Anal Carcinoma +

Anaplastic Oligodendroglioma +

Astrocytoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Biliary Tract Carcinoma +

Bronchogenic Carcinoma +

Carcinoma +

Cervical Squamous Cell Carcinoma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Ependymoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Gastrointestinal Stromal Tumor +

Glioblastoma, IDH-Wildtype +

Hepatobiliary Neoplasm +

High Grade Ovarian Serous Adenocarcinoma +

Hypopharyngeal Squamous Cell Carcinoma +

Kidney Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Lip And Oral Cavity Carcinoma +

Low Grade Glioma +

Lung Neuroendocrine Neoplasm +

Lymphoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Supratentorial Neoplasm +

Malignant Uterine Neoplasm +

Meningioma +

Mesothelioma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Neuroblastoma +

Neuroendocrine Carcinoma +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Ovarian Carcinosarcoma +

Ovarian Epithelial Tumor +

Pancreatic Ductal Adenocarcinoma +

Pituitary Gland Carcinoma +

Primary Peritoneal Carcinoma +

Primitive Neuroectodermal Tumor +

Prostate Carcinoma +

Renal Cell Carcinoma +

Rhabdomyosarcoma +

Skin Squamous Cell Carcinoma +

Small Intestinal Carcinoma +

Soft Tissue Sarcoma +

Thymic Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Ureter Carcinoma +

Uterine Carcinosarcoma +

Uveal Melanoma +

WHO Grade III Glioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.