Associated Genetic Biomarkers

Overview

NCI Definition: A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary. [1]

Biomarker-Directed Therapies

Significant Genes in Urothelial Carcinoma

ABL1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRD4 +

BRIP1 +

C11ORF30 +

CCND1 +

CDK12 +

CHEK1 +

CHEK2 +

CREBBP +

CRKL +

DDR2 +

DOT1L +

EGFR +

EP300 +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT4 +

FRK +

HDAC1 +

HDAC2 +

HRAS +

IKBKE +

KDR +

KIT +

KRAS +

MAPK11 +

MCPH1 +

MDC1 +

MDM2 +

MDM4 +

MEN1 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

POLD1 +

POLE +

POLQ +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD52 +

RAD54L +

RAF1 +

RB1 +

RBBP8 +

RECQL4 +

RET +

RICTOR +

ROS1 +

RPTOR +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TACC3 +

TEK +

TP53 +

TRNAK2 +

TSC1 +

TSC2 +

VEGFA +

VEGFB +

VEGFC +

WRN +

XRCC1 +

XRCC2 +

XRCC3 +

XRCC4 +

XRCC5 +

XRCC6 +

Disease Details

Synonyms
Transitional Cell Carcinoma of the Urinary Tract, Transitional cell carcinoma of the urothelial tract, Unknown primary urothelial carcinoma, Transitional cell car. -uroth., Uroepithelial Carcinoma
Parent(s)
Urothelial Neoplasm
Children
Urethral Urothelial Carcinoma, Renal Pelvis Papillary Urothelial Carcinoma, Bladder Urothelial Carcinoma, Primary Prostate Urothelial Carcinoma, and Renal Pelvis and Ureter Urothelial Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.