Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
13q12.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
CD135, STK1, FLK-2, FLK2

FLT3 (fms-related tyrosine kinase 3) encodes for the receptor-type tyrosine-protein kinase FLT3. FLT3 activates pathways in hematopoietic cells (Gene 2013). FLT3 is frequently mutated in acute myeloid leukemia, other hematologic malignancies, and colorectal cancer (COSMIC).

Biomarker-Directed Therapies

Significance of FLT3 in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Acute Biphenotypic Leukemia +

Chronic Lymphocytic Leukemia +

Mantle Cell Lymphoma +

Acute Leukemia +

Burkitt Lymphoma +

Myeloproliferative Neoplasm +

Secondary Acute Myeloid Leukemia +

Anaplastic Large Cell Lymphoma +

Follicular Lymphoma +

B-Cell Acute Lymphoblastic Leukemia +

Juvenile Myelomonocytic Leukemia +

Marginal Zone Lymphoma +

Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Myelofibrosis +

Prolymphocytic Leukemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Malignant Solid Tumor +

Mixed Phenotype Acute Leukemia +

Refractory Anemia With Excess Blasts +

Small Lymphocytic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Diffuse Large B-Cell Lymphoma +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

T-Cell Acute Lymphoblastic Leukemia +

Acute Promyelocytic Leukemia +

Acute Undifferentiated Leukemia +

Adult T-Cell Leukemia/Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Double-Hit Lymphoma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Myelodysplastic Syndrome With Excess Blasts-2 +

Therapy-Related Myelodysplastic Syndrome +

Plasma Cell Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

T-Cell Prolymphocytic Leukemia +

Acute Erythroid Leukemia +

Acute Megakaryoblastic Leukemia +

B-Cell Prolymphocytic Leukemia +

Bladder Carcinoma +

Breast Carcinoma +

Burkitt Leukemia +

Colorectal Carcinoma +

Head And Neck Carcinoma +

Mature T-Cell And NK-Cell Neoplasm +

Melanoma +

Myeloid Neoplasm +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Peripheral T-Cell Lymphoma +

Refractory Anemia +

Waldenstrom Macroglobulinemia +

Acute Bilineal Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Adenocarcinoma Of The Gastroesophageal Junction +

Adult Acute Lymphoblastic Leukemia +

Aggressive Systemic Mastocytosis +

Anaplastic Astrocytoma +

Angioimmunoblastic T-Cell Lymphoma +

Aplastic Anemia +

B-Cell Lymphoblastic Lymphoma +

Bile Duct Carcinoma +

Blastic Plasmacytoid Dendritic Cell Neoplasm +

Bronchogenic Carcinoma +

Cancer +

Cervical Carcinoma +

Desmoplastic Small Round Cell Tumor +

Esophageal Squamous Cell Carcinoma +

Ewing Sarcoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Glioblastoma +

Hepatosplenic T-Cell Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Indolent Non-Hodgkin Lymphoma +

Langerhans Cell Histiocytosis +

Leukemia +

Lung Carcinoma +

Malignant Uterine Neoplasm +

Mast Cell Leukemia +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Myelodysplastic Syndrome With Excess Blasts-1 +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Neuroblastoma +

Neurofibromatosis Type 1 +

Plasma Cell Neoplasm +

Polycythemia Vera +

Primary Myelofibrosis +

Prostate Carcinoma +

Rhabdomyosarcoma +

Sarcoma +

Secondary Myelodysplastic Syndrome +

Small Lymphocytic Leukemia +

Soft Tissue Sarcoma +

T-Cell Lymphoblastic Lymphoma +

T-Cell Non-Hodgkin Lymphoma +

T-Cell And NK-Cell Neoplasm +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myeloid Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.