Overview

Location [1]
13q12.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Receptor-type tyrosine-protein kinase FLT3
Synonyms [1]
STK1, FLK-2, FLK2, CD135

FLT3 (fms-related tyrosine kinase 3) encodes for the receptor-type tyrosine-protein kinase FLT3. FLT3 activates pathways in hematopoietic cells (Gene 2013). FLT3 is frequently mutated in acute myeloid leukemia, other hematologic malignancies, and colorectal cancer (COSMIC).

FLT3 is altered in 2.13% of all cancers with colon adenocarcinoma, acute myeloid leukemia, lung adenocarcinoma, breast invasive ductal carcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

FLT3 GENIE Cases - Top Diseases

The most common alterations in FLT3 are FLT3 Mutation (2.68%), FLT3 Amplification (0.51%), FLT3 D593_F594insNS (0.14%), FLT3 Loss (0.11%), and FLT3 Codon 835 Missense (0.09%) [3].

FLT3 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of FLT3 in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Acute Biphenotypic Leukemia +

Chronic Lymphocytic Leukemia +

Mantle Cell Lymphoma +

Acute Leukemia +

Burkitt Lymphoma +

Myeloproliferative Neoplasm +

Anaplastic Large Cell Lymphoma +

Follicular Lymphoma +

Secondary Acute Myeloid Leukemia +

Juvenile Myelomonocytic Leukemia +

Marginal Zone Lymphoma +

Lymphoma +

Malignant Solid Tumor +

Myelofibrosis +

Prolymphocytic Leukemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Refractory Anemia With Excess Blasts +

Small Lymphocytic Lymphoma +

B-Cell Acute Lymphoblastic Leukemia +

Diffuse Large B-Cell Lymphoma +

Lymphoplasmacytic Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Acute Undifferentiated Leukemia +

Adult T-Cell Leukemia/Lymphoma +

Double-Hit Lymphoma +

Lymphoblastic Lymphoma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mixed Phenotype Acute Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Acute Promyelocytic Leukemia +

Plasma Cell Leukemia +

Refractory Anemia With Excess Blasts-2 +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Prolymphocytic Leukemia +

Melanoma +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Bladder Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Pancreatic Carcinoma +

Acute Erythroid Leukemia +

Acute Megakaryoblastic Leukemia +

B-Cell Prolymphocytic Leukemia +

Burkitt Leukemia +

Head And Neck Carcinoma +

Mature T-Cell And NK-Cell Neoplasm +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Peripheral T-Cell Lymphoma +

Refractory Anemia +

Waldenstrom Macroglobulinemia +

Leukemia +

B-Cell Lymphoblastic Leukemia/Lymphoma +

Malignant Uterine Neoplasm +

Anaplastic Astrocytoma +

Glioblastoma +

Lung Carcinoma +

Cancer +

Cervical Carcinoma +

Esophageal Carcinoma +

Bile Duct Carcinoma +

Sarcoma +

Acute Bilineal Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Adenocarcinoma Of The Gastroesophageal Junction +

Adult Acute Lymphoblastic Leukemia +

Aggressive Systemic Mastocytosis +

Angioimmunoblastic T-Cell Lymphoma +

Aplastic Anemia +

Blastic Plasmacytoid Dendritic Cell Neoplasm +

Bronchogenic Carcinoma +

Desmoplastic Small Round Cell Tumor +

Esophageal Squamous Cell Carcinoma +

Ewing Sarcoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Hepatosplenic T-Cell Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Indolent Non-Hodgkin Lymphoma +

Langerhans Cell Histiocytosis +

Mast Cell Leukemia +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Neuroblastoma +

Neurofibromatosis Type 1 +

Plasma Cell Neoplasm +

Polycythemia Vera +

Primary Myelofibrosis +

Refractory Anemia With Excess Blasts-1 +

Rhabdomyosarcoma +

Secondary Myelodysplastic Syndrome +

Small Lymphocytic Leukemia +

T-Cell Non-Hodgkin Lymphoma +

T-Cell And NK-Cell Neoplasm +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myeloid Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.