Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
7q34
Pathways
MAP kinase signaling, Kinase fusions
Protein [2]
Serine/threonine-protein kinase B-raf
Synonyms [1]
BRAF1, NS7, B-raf, RAFB1, B-RAF1

BRAF (B-Raf proto-oncogene, serine/threonine kinase) is a gene that encodes the protein serine/threonine-protein kinase B-raf. BRAF is involved in many cellular processes, including cell proliferation, differentiation, and transcriptional regulation. Mutant BRAF has been implicated in the pathogenesis of several cancers, including melanoma, non-small cell lung cancer, colorectal cancer, papillary thyroid cancer, and ovarian cancer (PMID: 12068308).

BRAF is altered in 5.17% of all cancers with colon adenocarcinoma, cutaneous melanoma, lung adenocarcinoma, melanoma, and thyroid gland papillary carcinoma having the greatest prevalence of alterations [3].

BRAF GENIE Cases - Top Diseases

The most common alterations in BRAF are BRAF Mutation (7.58%), BRAF Exon 15 Mutation (5.58%), BRAF Codon 600 Missense (4.49%), BRAF V600E (4.25%), and BRAF Codon 469 Missense (0.40%) [3].

BRAF GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of BRAF in Diseases

Melanoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Thyroid Gland Papillary Carcinoma +

Hairy Cell Leukemia +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Thyroid Gland Follicular Carcinoma +

Erdheim-Chester Disease +

Pilocytic Astrocytoma +

Pleomorphic Xanthoastrocytoma +

Ganglioglioma +

Mature B-Cell Lymphoma/Leukemia +

Malignant Solid Tumor +

Glioma +

Multiple Myeloma +

Cutaneous Melanoma +

Pancreatic Carcinoma +

Cancer +

Ovarian Carcinoma +

Breast Carcinoma +

Colorectal Adenocarcinoma +

Non-Hodgkin Lymphoma +

Thyroid Gland Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Low Grade Glioma +

Squamous Cell Lung Carcinoma +

Gastric Carcinoma +

Esophageal Carcinoma +

Melanoma Of Unknown Primary +

Thyroid Gland Adenocarcinoma +

Cholangiocarcinoma +

Bladder Carcinoma +

Malignant Glioma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Anaplastic Pleomorphic Xanthoastrocytoma +

Langerhans Cell Histiocytosis +

Colon Carcinoma +

Lung Carcinoma +

Urothelial Carcinoma +

Lymphoma +

Neuroblastoma +

Pancreatic Adenocarcinoma +

Malignant Salivary Gland Neoplasm +

Germ Cell Tumor +

Renal Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Squamous Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Histiocytosis +

Non-Squamous Non-Small Cell Lung Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Colon Adenocarcinoma +

Mucosal Melanoma +

Small Intestinal Adenocarcinoma +

Skin Squamous Cell Carcinoma +

Solid Neoplasm +

Rectal Carcinoma +

Malignant Central Nervous System Neoplasm +

Bile Duct Carcinoma +

Endometrial Carcinoma +

Biliary Tract Carcinoma +

Glioblastoma +

Chronic Lymphocytic Leukemia +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Malignant Uterine Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Hepatocellular Carcinoma +

Small Cell Lung Carcinoma +

Gastric Adenocarcinoma +

Squamous Cell Carcinoma +

Cervical Carcinoma +

Prostate Carcinoma +

Soft Tissue Sarcoma +

Acute Myeloid Leukemia +

Ameloblastoma +

Anaplastic Ganglioglioma +

Bronchogenic Carcinoma +

Cervical Squamous Cell Carcinoma +

Chronic Myelomonocytic Leukemia +

Embryonal Rhabdomyosarcoma +

Gallbladder Carcinoma +

Histiocytic Sarcoma +

Hodgkin Lymphoma +

Juvenile Xanthogranuloma +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Peripheral Nerve Sheath Tumor +

Metastatic Malignant Neoplasm In The Brain +

Myelodysplastic Syndromes +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neurofibroma +

Neurofibromatosis Type 1 +

Optic Nerve Glioma +

Oropharyngeal Carcinoma +

Papillary Craniopharyngioma +

Rhabdoid Tumor +

Schwannoma +

Splenic Diffuse Red Pulp Small B-Cell Lymphoma +

Thymic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.