Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
11p15.5
Pathway
MAP kinase signaling
Synonyms [1]
C-H-RAS, HRAS1, CTLO, HAMSV, p21ras, C-BAS/HAS, RASH1, H-RASIDX, C-HA-RAS1

HRAS (Harvey rat sarcoma viral oncogene homolog) encodes the GTPase HRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. HRAS is implicated in the pathogenesis of several cancers.

 

Significance of HRAS in Diseases

Malignant Solid Tumor +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Melanoma +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Ovarian Carcinoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Acute Lymphoblastic Leukemia +

Cancer +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Low Grade Glioma +

Multiple Myeloma +

Neurofibromatosis Type 1 +

Pancreatic Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Small Cell Lung Carcinoma +

Squamous Cell Carcinoma +

Astrocytic Tumor +

Breast Carcinoma +

Cholangiocarcinoma +

Chronic Myeloid Leukemia +

Colorectal Adenocarcinoma +

Cutaneous Melanoma +

Diffuse Glioma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Gangliocytoma +

Ganglioglioma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Histiocytosis +

Juvenile Myelomonocytic Leukemia +

Low Grade Ovarian Serous Adenocarcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Lung Adenocarcinoma +

Lymphoma +

Malignant Peripheral Nerve Sheath Tumor +

Malignant Thyroid Gland Neoplasm +

Mantle Cell Lymphoma +

Mucosal Melanoma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myeloid Neoplasm +

Neuroblastoma +

Neuronal And Mixed Neuronal-Glial Tumors +

Pancreatic Adenocarcinoma +

Peripheral T-Cell Lymphoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Secondary Acute Myeloid Leukemia +

Soft Tissue Sarcoma +

Therapy-Related Acute Myeloid Leukemia +

Thymic Carcinoma +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Papillary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.