Overview

Location [1]
11p15.5
Pathway
MAP kinase signaling
Protein [2]
GTPase HRas, N-terminally processed
Synonyms [1]
C-H-RAS, HRAS1, RASH1, p21ras, C-BAS/HAS, H-RASIDX, CTLO, C-HA-RAS1, HAMSV

HRAS (Harvey rat sarcoma viral oncogene homolog) encodes the GTPase HRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. HRAS is implicated in the pathogenesis of several cancers.

 

HRAS is altered in 1.10% of all cancers with breast carcinoma, thyroid gland neoplasm, melanoma, leukemia, and bladder carcinoma having the greatest prevalence of alterations [3].

HRAS GENIE Cases - Top Diseases

The most common alterations in HRAS are HRAS Mutation (1.32%), HRAS Missense (1.08%), HRAS Q22Pfs*26 (0.19%), HRAS Q61R (0.17%), and HRAS Loss (0.11%) [3].

HRAS GENIE Cases - Top Alterations

Significance of HRAS in Diseases

Malignant Solid Tumor +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Myelodysplastic Syndromes +

Acute Myeloid Leukemia +

Non-Hodgkin Lymphoma +

Melanoma +

Chronic Myelomonocytic Leukemia +

Head And Neck Squamous Cell Carcinoma +

Glioma +

Squamous Cell Lung Carcinoma +

Multiple Myeloma +

Small Cell Lung Carcinoma +

Neuroblastoma +

Acute Lymphoblastic Leukemia +

Cancer +

Neurofibromatosis Type 1 +

Ovarian Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Adenocarcinoma +

Thyroid Gland Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Urothelial Carcinoma +

Chronic Myeloid Leukemia +

Rhabdomyosarcoma +

Thyroid Gland Papillary Carcinoma +

Thymic Carcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Endometrial Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Diffuse Large B-Cell Lymphoma +

Soft Tissue Sarcoma +

Prostate Carcinoma +

Breast Carcinoma +

Renal Cell Carcinoma +

Hepatocellular Carcinoma +

Double-Hit Lymphoma +

Malignant Thyroid Gland Neoplasm +

Mantle Cell Lymphoma +

Pancreatic Carcinoma +

Peripheral T-Cell Lymphoma +

Rhabdoid Tumor +

Schwannoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.