Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
12p12.1
Pathway
MAP kinase signaling
Protein [2]
GTPase KRas, N-terminally processed
Synonyms [1]
RASK2, K-Ras, NS, CFC2, C-K-RAS, K-RAS4A, KI-RAS, RALD, KRAS1, K-RAS4B, K-RAS2B, KRAS2, K-RAS2A, c-Ki-ras2, NS3

KRAS (Kirsten rat sarcoma viral oncogene homolog) encodes for the GTPase KRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. KRAS is implicated in the pathogenesis of several cancers.

KRAS is altered in 13.96% of all cancers with lung adenocarcinoma, colon adenocarcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and rectal adenocarcinoma having the greatest prevalence of alterations [3].

KRAS GENIE Cases - Top Diseases

The most common alterations in KRAS are KRAS Mutation (20.55%), KRAS Mutation (germline) (20.55%), KRAS Mutation (somatic) (20.55%), KRAS Exon 2 Mutation (18.21%), and KRAS Codon 12 Missense (15.92%) [3].

KRAS GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of KRAS in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Pancreatic Carcinoma +

Acute Myeloid Leukemia +

Colorectal Adenocarcinoma +

Melanoma +

Myelodysplastic Syndromes +

Breast Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Non-Hodgkin Lymphoma +

Pancreatic Adenocarcinoma +

Chronic Myelomonocytic Leukemia +

Ovarian Carcinoma +

Multiple Myeloma +

Lung Adenocarcinoma +

Cancer +

Acute Lymphoblastic Leukemia +

Bladder Carcinoma +

Squamous Cell Lung Carcinoma +

Glioma +

Colon Carcinoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Renal Cell Carcinoma +

Prostate Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Neurofibromatosis Type 1 +

Urothelial Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Small Cell Lung Carcinoma +

Glioblastoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Diffuse Large B-Cell Lymphoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Malignant Small Intestinal Neoplasm +

Malignant Intestinal Neoplasm +

Colorectal Neoplasm +

Rectal Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Adenocarcinoma +

Lung Carcinoma +

Malignant Testicular Neoplasm +

Cholangiocarcinoma +

Germ Cell Tumor +

Malignant Ovarian Epithelial Tumor +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Gastric Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Papillary Renal Cell Carcinoma +

Lymphoma +

Thyroid Gland Carcinoma +

Anaplastic Astrocytoma +

High Grade Ovarian Serous Adenocarcinoma +

Thyroid Gland Adenocarcinoma +

Thyroid Gland Papillary Carcinoma +

Sarcoma +

Soft Tissue Sarcoma +

Breast Adenocarcinoma +

Kidney Carcinoma +

Ampulla Of Vater Carcinoma +

Cervical Squamous Cell Carcinoma +

Chronic Myeloid Leukemia +

Clear Cell Renal Cell Carcinoma +

Double-Hit Lymphoma +

Esophageal Squamous Cell Carcinoma +

Juvenile Myelomonocytic Leukemia +

Malignant Peripheral Nerve Sheath Tumor +

Mantle Cell Lymphoma +

Mesothelioma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Non-Squamous Non-Small Cell Lung Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Peripheral T-Cell Lymphoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Refractory Anemia With Excess Blasts +

Refractory Anemia With Excess Blasts-2 +

Rhabdoid Tumor +

Rhabdomyosarcoma +

Schwannoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Thymic Carcinoma +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.