Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
12p12.1
Pathway
MAP kinase signaling
Protein [2]
GTPase KRas, N-terminally processed
Synonyms [1]
K-RAS4A, C-K-RAS, RASK2, RALD, NS, K-RAS4B, NS3, KRAS2, K-RAS2B, KI-RAS, K-RAS2A, CFC2, KRAS1, K-Ras, c-Ki-ras2

KRAS (Kirsten rat sarcoma viral oncogene homolog) encodes for the GTPase KRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. KRAS is implicated in the pathogenesis of several cancers.

KRAS is altered in 13.96% of all cancers with lung adenocarcinoma, colon adenocarcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and rectal adenocarcinoma having the greatest prevalence of alterations [3].

KRAS GENIE Cases - Top Diseases

The most common alterations in KRAS are KRAS Mutation (20.55%), KRAS Exon 2 Mutation (18.21%), KRAS Codon 12 Missense (15.92%), KRAS G12D (5.57%), and KRAS G12V (4.61%) [3].

KRAS GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of KRAS in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Pancreatic Carcinoma +

Acute Myeloid Leukemia +

Colorectal Adenocarcinoma +

Melanoma +

Myelodysplastic Syndromes +

Breast Carcinoma +

Ovarian Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Pancreatic Adenocarcinoma +

Chronic Myelomonocytic Leukemia +

Squamous Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Lung Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Multiple Myeloma +

Cancer +

Acute Lymphoblastic Leukemia +

Esophageal Carcinoma +

Bladder Carcinoma +

Colon Carcinoma +

Endometrial Carcinoma +

Gastric Carcinoma +

Glioma +

Renal Cell Carcinoma +

Glioblastoma +

Prostate Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatocellular Carcinoma +

Cholangiocarcinoma +

Urothelial Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Small Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Cutaneous Melanoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Diffuse Large B-Cell Lymphoma +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Neurofibromatosis Type 1 +

Non-Squamous Non-Small Cell Lung Carcinoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Malignant Small Intestinal Neoplasm +

Malignant Intestinal Neoplasm +

Malignant Colorectal Neoplasm +

Rectal Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Adenocarcinoma +

Lung Carcinoma +

Malignant Testicular Neoplasm +

Germ Cell Tumor +

Malignant Ovarian Epithelial Tumor +

Malignant Gastric Neoplasm +

Gastric Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Papillary Renal Cell Carcinoma +

Lymphoma +

Anaplastic Astrocytoma +

High Grade Ovarian Serous Adenocarcinoma +

Low Grade Glioma +

Squamous Cell Carcinoma +

Thyroid Gland Papillary Carcinoma +

Sarcoma +

Soft Tissue Sarcoma +

Breast Adenocarcinoma +

Kidney Carcinoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Ampulla Of Vater Carcinoma +

Anal Canal Squamous Cell Carcinoma +

Cervical Squamous Cell Carcinoma +

Chordoma +

Chronic Myeloid Leukemia +

Clear Cell Renal Cell Carcinoma +

Double-Hit Lymphoma +

Embryonal Rhabdomyosarcoma +

Esophageal Squamous Cell Carcinoma +

Juvenile Myelomonocytic Leukemia +

Malignant Peripheral Nerve Sheath Tumor +

Mantle Cell Lymphoma +

Mesothelioma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Oropharyngeal Squamous Cell Carcinoma +

Peripheral T-Cell Lymphoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Refractory Anemia With Excess Blasts +

Refractory Anemia With Excess Blasts-2 +

Rhabdoid Tumor +

Schwannoma +

Therapy-Related Myelodysplastic Syndrome +

Thymic Carcinoma +

Thyroid Gland Follicular Carcinoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.