Associated Genetic Biomarkers

Overview

Gene Location [1]
12p12.1
Pathway
MAP kinase signaling
Gene
KRAS

KRAS Mutation is present in 13.14% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and rectal adenocarcinoma having the greatest prevalence [4].

Top Disease Cases with KRAS Mutation

Significance of KRAS Mutation in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Melanoma +

Acute Myeloid Leukemia +

Pancreatic Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Non-Hodgkin Lymphoma +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Pancreatic Adenocarcinoma +

Colorectal Adenocarcinoma +

Lung Adenocarcinoma +

Acute Lymphoblastic Leukemia +

Bladder Carcinoma +

Esophageal Carcinoma +

Multiple Myeloma +

Colon Carcinoma +

Endometrial Carcinoma +

Renal Cell Carcinoma +

Prostate Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Cholangiocarcinoma +

Cancer +

Gastric Carcinoma +

Urothelial Carcinoma +

Squamous Cell Lung Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Cutaneous Melanoma +

Glioma +

Glioblastoma +

Diffuse Large B-Cell Lymphoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Myelodysplastic Syndrome With Excess Blasts-2 +

Neuroblastoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Malignant Small Intestinal Neoplasm +

Malignant Intestinal Neoplasm +

Low Grade Ovarian Serous Adenocarcinoma +

Lung Carcinoma +

Germ Cell Tumor +

Malignant Ovarian Epithelial Tumor +

Malignant Testicular Neoplasm +

Malignant Gastric Neoplasm +

Malignant Esophagogastric Neoplasm +

Papillary Renal Cell Carcinoma +

Lymphoma +

Myeloid Neoplasm +

Small Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Low Grade Glioma +

Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Thyroid Gland Papillary Carcinoma +

Sarcoma +

Soft Tissue Sarcoma +

Kidney Carcinoma +

Breast Adenocarcinoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Adenocarcinoma Of The Gastroesophageal Junction +

Ampulla Of Vater Carcinoma +

Anaplastic Astrocytoma +

Cervical Squamous Cell Carcinoma +

Chronic Myeloid Leukemia +

Clear Cell Renal Cell Carcinoma +

Double-Hit Lymphoma +

Embryonal Rhabdomyosarcoma +

Malignant Peripheral Nerve Sheath Tumor +

Mantle Cell Lymphoma +

Mesothelioma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Neurofibromatosis Type 1 +

Oropharyngeal Squamous Cell Carcinoma +

Peripheral T-Cell Lymphoma +

Peritoneal Mesothelioma +

Pleural Mesothelioma +

Rhabdoid Tumor +

Schwannoma +

Therapy-Related Myelodysplastic Syndrome +

Thymic Carcinoma +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.