Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Gene Location [1]
MAP kinase signaling

KRAS Mutation is present in 15.12% of AACR GENIE cases, with lung adenocarcinoma, pancreatic adenocarcinoma, colon adenocarcinoma, colorectal adenocarcinoma, and rectal adenocarcinoma having the greatest prevalence [4].

Top Disease Cases with KRAS Mutation

Significance of KRAS Mutation in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Acute Myeloid Leukemia +

Melanoma +

Pancreatic Carcinoma +

Myelodysplastic Syndromes +

Breast Carcinoma +

Colorectal Adenocarcinoma +

Lung Adenocarcinoma +

Ovarian Carcinoma +

Chronic Myelomonocytic Leukemia +

Squamous Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Pancreatic Adenocarcinoma +

Multiple Myeloma +

Bladder Carcinoma +

Esophageal Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Colon Carcinoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Cancer +

Head And Neck Squamous Cell Carcinoma +

Glioma +

Renal Cell Carcinoma +

Hepatocellular Carcinoma +

Prostate Carcinoma +

Acute Lymphoblastic Leukemia +

Ampulla Of Vater Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Gastric Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Urothelial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Poorly Differentiated Thyroid Gland Carcinoma +

Small Cell Lung Carcinoma +

Low Grade Glioma +

Lymphoma +

Secondary Acute Myeloid Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Thyroid Gland Carcinoma +

Cutaneous Melanoma +

Diffuse Large B-Cell Lymphoma +

Head And Neck Carcinoma +

Glioblastoma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Gastrointestinal Stromal Tumor +

Malignant Small Intestinal Neoplasm +

Malignant Intestinal Neoplasm +

Lung Carcinoma +

Biliary Tract Carcinoma +

Germ Cell Tumor +

Malignant Gastric Neoplasm +

Gastric Adenocarcinoma +

Malignant Testicular Neoplasm +

Malignant Ovarian Epithelial Tumor +

Gallbladder Carcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Peripheral Nerve Sheath Tumor +

Mucosal Melanoma +

Papillary Renal Cell Carcinoma +

Pilocytic Astrocytoma +

Myeloid Neoplasm +

Therapy-Related Myelodysplastic Syndrome +

Embryonal Rhabdomyosarcoma +

Squamous Cell Carcinoma +

Thyroid Gland Follicular Carcinoma +

Ganglioglioma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Cervical Squamous Cell Carcinoma +

Mantle Cell Lymphoma +

Neuroblastoma +

High Grade Ovarian Serous Adenocarcinoma +

Sarcoma +

Oropharyngeal Squamous Cell Carcinoma +

Thyroid Gland Papillary Carcinoma +

Soft Tissue Sarcoma +

Diffuse Glioma +

Neuronal And Mixed Neuronal-Glial Tumors +

Astrocytic Tumor +

Kidney Carcinoma +

Chronic Myeloid Leukemia +

Breast Adenocarcinoma +

Anaplastic Astrocytoma +

Pleural Mesothelioma +

Mesothelioma +

Clear Cell Renal Cell Carcinoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

B-Cell Acute Lymphoblastic Leukemia +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Low-Grade Neuroepithelial Tumor, NOS +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Neurofibromatosis Type 1 +

Peripheral T-Cell Lymphoma +

Peritoneal Mesothelioma +

Pilomyxoid Astrocytoma +

Primary Peritoneal Low Grade Serous Adenocarcinoma +

Rhabdoid Tumor +

Schwannoma +

T-Cell Acute Lymphoblastic Leukemia +

Thymic Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.