Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Gene Location [1]
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type

NTRK3 Fusion is present in 0.15% of AACR GENIE cases, with mammary analog secretory carcinoma of salivary gland, breast invasive ductal carcinoma, colon adenocarcinoma, thyroid gland papillary carcinoma, and unknown having the greatest prevalence [4].

Top Disease Cases with NTRK3 Fusion

Biomarker-Directed Therapies

Significance of NTRK3 Fusion in Diseases

Malignant Solid Tumor +

Acute Lymphoblastic Leukemia +

Non-Small Cell Lung Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Congenital Mesoblastic Nephroma +

Infantile Fibrosarcoma +

Breast Carcinoma +

Colorectal Carcinoma +

Melanoma +

Anaplastic Large Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Lymphoma +

Mixed Phenotype Acute Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Secretory Breast Carcinoma +

Malignant Colorectal Neoplasm +

Central Nervous System Neoplasm +

Malignant Glioma +

Lung Adenocarcinoma +

Lung Carcinoma +

Acute Leukemia +

B-Cell Lymphoblastic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Desmoplastic Small Round Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Lymphoblastic Lymphoma +

Malignant Ovarian Neoplasm +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Secondary Acute Myeloid Leukemia +

Squamous Cell Lung Carcinoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.