Gene Location [1]
Cell cycle control
Variant Type

TP53 Loss is present in 0.48% of AACR GENIE cases, with sarcoma, breast carcinoma, prostate cancer, non-small cell lung carcinoma, and malignant glioma having the greatest prevalence [4].

Top Disease Cases with TP53 Loss

Significance of TP53 Loss in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Colorectal Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Glioblastoma +

Pancreatic Carcinoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Sarcoma +

Diffuse Large B-Cell Lymphoma +

Anaplastic Astrocytoma +

Head And Neck Carcinoma +

Lymphoma +

Urothelial Carcinoma +

Bladder Urothelial Carcinoma +

Bladder Carcinoma +

Melanoma +

Colorectal Adenocarcinoma +

Breast Lobular Carcinoma In Situ +

Cancer +

Chronic Lymphocytic Leukemia +

Esophageal Squamous Cell Carcinoma +

Hereditary Breast And Ovarian Cancer Syndrome +

Infiltrating Renal Pelvis And Ureter Urothelial Carcinoma +

Myeloma +

Renal Pelvis Urothelial Carcinoma +

Small Lymphocytic Lymphoma +

Smoldering Plasma Cell Myeloma +

T-Cell Non-Hodgkin Lymphoma +

Ureter Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.