Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
1p13.2
Pathway
MAP kinase signaling
Synonyms [1]
CMNS, ALPS4, NCMS, NRAS1, N-ras, NS6

NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog) encodes for the GTPase NRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. NRAS is implicated in the pathogenesis of several cancers (for review see PMID: 17384584).

Biomarker-Directed Therapies

Significance of NRAS in Diseases

Melanoma +

Malignant Solid Tumor +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Colorectal Adenocarcinoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Pancreatic Carcinoma +

Cutaneous Melanoma +

Ovarian Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Acute Lymphoblastic Leukemia +

Cancer +

Glioma +

Neurofibromatosis Type 1 +

Thyroid Gland Carcinoma +

Breast Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Juvenile Myelomonocytic Leukemia +

Low Grade Glioma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Poorly Differentiated Thyroid Gland Carcinoma +

Secondary Acute Myeloid Leukemia +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Therapy-Related Acute Myeloid Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Astrocytoma +

Astrocytic Tumor +

B-Cell Acute Lymphoblastic Leukemia +

Bladder Carcinoma +

Cholangiocarcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia-0 +

Chronic Myelomonocytic Leukemia-1 +

Chronic Myelomonocytic Leukemia-2 +

Colon Carcinoma +

Diffuse Glioma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Gangliocytoma +

Ganglioglioma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Lung Adenocarcinoma +

Lung Carcinoma +

Lymphoma +

Malignant Peripheral Nerve Sheath Tumor +

Mantle Cell Lymphoma +

Mucosal Melanoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloid Neoplasm +

Neuroblastoma +

Neuronal And Mixed Neuronal-Glial Tumors +

Pancreatic Adenocarcinoma +

Peripheral T-Cell Lymphoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Prostate Carcinoma +

Rectal Carcinoma +

Refractory Anemia With Excess Blasts +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Sarcoma +

Schwannoma +

Secondary Myelodysplastic Syndrome +

Soft Tissue Sarcoma +

Squamous Cell Carcinoma +

T-Cell Acute Lymphoblastic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Thymic Carcinoma +

Thyroid Gland Follicular Carcinoma +

Thyroid Gland Papillary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.