Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
1p13.2
Pathway
MAP kinase signaling
Protein [2]
GTPase NRas
Synonyms [1]
NCMS, ALPS4, N-ras, CMNS, NS6, NRAS1

NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog) encodes for the GTPase NRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. NRAS is implicated in the pathogenesis of several cancers (for review see PMID: 17384584).

NRAS is altered in 2.57% of all cancers with cutaneous melanoma, melanoma, colon adenocarcinoma, acute myeloid leukemia, and lung adenocarcinoma having the greatest prevalence of alterations [3].

NRAS GENIE Cases - Top Diseases

The most common alterations in NRAS are NRAS Mutation (3.80%), NRAS Exon 3 Mutation (2.57%), NRAS Exon 3 Missense (2.55%), NRAS Codon 61 Missense (2.33%), and NRAS Exon 2 Mutation (1.12%) [3].

NRAS GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of NRAS in Diseases

Melanoma +

Malignant Solid Tumor +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Colorectal Adenocarcinoma +

Non-Hodgkin Lymphoma +

Pancreatic Carcinoma +

Multiple Myeloma +

Acute Lymphoblastic Leukemia +

Ovarian Carcinoma +

Cancer +

Glioma +

Pancreatic Ductal Adenocarcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Cutaneous Melanoma +

Thyroid Gland Carcinoma +

Squamous Cell Lung Carcinoma +

Breast Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Myelodysplastic Syndrome With Excess Blasts-2 +

Neuroblastoma +

Neurofibromatosis Type 1 +

Secondary Acute Myeloid Leukemia +

Small Cell Lung Carcinoma +

Therapy-Related Acute Myeloid Leukemia +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Thyroid Gland Follicular Carcinoma +

Embryonal Rhabdomyosarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Thyroid Gland Papillary Carcinoma +

Myeloid Neoplasm +

Rectal Carcinoma +

Colon Carcinoma +

Lymphoma +

Cholangiocarcinoma +

Endometrial Carcinoma +

Soft Tissue Sarcoma +

Bladder Carcinoma +

Sarcoma +

Esophageal Carcinoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Squamous Cell Carcinoma +

Glioblastoma +

Pancreatic Adenocarcinoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Astrocytoma +

Chronic Myeloid Leukemia +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Juvenile Myelomonocytic Leukemia +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Mantle Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Peripheral T-Cell Lymphoma +

Prostate Carcinoma +

Refractory Anemia With Excess Blasts +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Secondary Myelodysplastic Syndrome +

Therapy-Related Myelodysplastic Syndrome +

Thymic Carcinoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.