Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
1q23.1
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Protein [2]
High affinity nerve growth factor receptor
Synonyms [1]
MTC, Trk-A, p140-TrkA, TRK, TRK1, TRKA

NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) encodes the high affinity nerve growth factor receptor protein. NTRK1 fusions have been observed in colorectal cancer (PMID: 2869410), papillary thyroid cancer (PMID: 19883730), lung cancer (PMID: 24162815), glioblastoma (PMID: 19883730; PMID: 24647444), and cholangiocarcinoma (PMID: 24563076). NTRK1 fusions trigger constitutive TRKA kinase activity (PMID: 24162815), which activates cell growth and differentiation pathways (PMID: 12652644).

NTRK1 is altered in 2.21% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, cutaneous melanoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

NTRK1 GENIE Cases - Top Diseases

The most common alterations in NTRK1 are NTRK1 Mutation (2.09%), NTRK1 Amplification (0.43%), NTRK1 R214W (0.03%), NTRK1 R157H (0.02%), and NTRK1 T434M (0.02%) [3].

NTRK1 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of NTRK1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Lymphoma +

Non-Hodgkin Lymphoma +

Congenital Mesoblastic Nephroma +

Infantile Fibrosarcoma +

Melanoma +

Colorectal Carcinoma +

Breast Carcinoma +

Anaplastic Large Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Hepatocellular Carcinoma +

Acute Leukemia +

Acute Myeloid Leukemia +

Ovarian Carcinoma +

Malignant Central Nervous System Neoplasm +

Esophagogastric Carcinoma +

Prostate Carcinoma +

Pancreatic Carcinoma +

Adenoid Cystic Carcinoma +

Cervical Carcinoma +

Hematopoietic And Lymphoid Malignancy +

Histiocytic And Dendritic Cell Neoplasm +

Mesothelioma +

Multiple Myeloma +

Secretory Breast Carcinoma +

Thymic Carcinoma +

Thymoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.