Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
15q25.3
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
TRKC, GP145-TrkC, gp145(trkC)

Neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) is a gene that encodes a protein that belongs to the neurotrophic tyrosine kinase (NTRK) family. The protein functions in the phosphorylation of members of the MAP kinase pathway, cell differentiation, and the development of proprioceptive neurons. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

Biomarker-Directed Therapies

Significance of NTRK3 in Diseases

Malignant Solid Tumor +

Acute Lymphoblastic Leukemia +

Non-Small Cell Lung Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Breast Carcinoma +

Colorectal Carcinoma +

Congenital Mesoblastic Nephroma +

Infantile Fibrosarcoma +

Melanoma +

Anaplastic Large Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Lung Carcinoma +

Lymphoma +

Mixed Phenotype Acute Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Acute Leukemia +

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Lymphoblastic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bladder Carcinoma +

Bronchogenic Carcinoma +

Central Nervous System Neoplasm +

Cervical Carcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Desmoplastic Small Round Cell Tumor +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Lung Adenocarcinoma +

Lymphoblastic Lymphoma +

Malignant Colorectal Neoplasm +

Malignant Glioma +

Malignant Ovarian Neoplasm +

Malignant Uterine Neoplasm +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Secondary Acute Myeloid Leukemia +

Secretory Breast Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.