Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Location [1]
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Protein [2]
NT-3 growth factor receptor
Synonyms [1]
GP145-TrkC, TRKC, gp145(trkC)

Neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) is a gene that encodes a protein that belongs to the neurotrophic tyrosine kinase (NTRK) family. The protein functions in the phosphorylation of members of the MAP kinase pathway, cell differentiation, and the development of proprioceptive neurons. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

NTRK3 is altered in 2.75% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

NTRK3 GENIE Cases - Top Diseases

The most common alterations in NTRK3 are NTRK3 Mutation (2.35%), NTRK3 Fusion (0.15%), NTRK3 Amplification (0.11%), NTRK3 Loss (0.09%), and NTRK3-ETV6 Fusion (0.05%) [3].

NTRK3 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of NTRK3 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Acute Lymphoblastic Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Melanoma +

Colorectal Carcinoma +

Breast Carcinoma +

Acute Myeloid Leukemia +

Congenital Mesoblastic Nephroma +

Infantile Fibrosarcoma +

Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Multiple Myeloma +

Lymphoma +

Non-Hodgkin Lymphoma +

Myelodysplastic Syndromes +

Anaplastic Large Cell Lymphoma +

Mixed Phenotype Acute Leukemia +

Secretory Breast Carcinoma +

Squamous Cell Lung Carcinoma +

Lung Adenocarcinoma +

Malignant Colorectal Neoplasm +

Gastric Adenocarcinoma +

Bladder Carcinoma +

Malignant Uterine Neoplasm +

Adenocarcinoma Of The Gastroesophageal Junction +

Head And Neck Carcinoma +

Ovarian Carcinoma +

Malignant Ovarian Neoplasm +

Esophageal Squamous Cell Carcinoma +

Bile Duct Carcinoma +

Gallbladder Carcinoma +

Cervical Carcinoma +

Malignant Glioma +

Soft Tissue Sarcoma +

Central Nervous System Neoplasm +

Pancreatic Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Acute Leukemia +

B-Cell Lymphoblastic Lymphoma +

Bronchogenic Carcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Desmoplastic Small Round Cell Tumor +

Lymphoblastic Lymphoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Secondary Acute Myeloid Leukemia +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.