Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
15q25.3
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Protein [2]
NT-3 growth factor receptor
Synonyms [1]
gp145(trkC), GP145-TrkC, TRKC

Neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) is a gene that encodes a protein that belongs to the neurotrophic tyrosine kinase (NTRK) family. The protein functions in the phosphorylation of members of the MAP kinase pathway, cell differentiation, and the development of proprioceptive neurons. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

NTRK3 is altered in 2.41% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, squamous cell lung carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

NTRK3 GENIE Cases - Top Diseases

The most common alterations in NTRK3 are NTRK3 Mutation (2.61%), NTRK3 Amplification (0.10%), NTRK3 Loss (0.04%), NTRK3 K746T (0.02%), and NTRK3 R306H (0.02%) [3].

NTRK3 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of NTRK3 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Congenital Mesoblastic Nephroma +

Infantile Fibrosarcoma +

Colorectal Carcinoma +

Lymphoma +

Anaplastic Large Cell Lymphoma +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Melanoma +

Malignant Central Nervous System Neoplasm +

Breast Carcinoma +

Acute Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Secretory Breast Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.