Pathways /
Kinase fusions
Overview
Kinase fusion cell signaling pathways promote gene transcription, cell growth, proliferation, differentiation, and survival. These pathways also play a role in cellular metabolic regulation. Kinase fusions are abnormal genome alterations in tumor cells that result from the aberrant rearrangement of translocation of two genes, one of which encodes a protein kinase. [1]
![](https://storage.googleapis.com/mycancergenome/pathways/Kinase_Fusions_FINAL_DRAFT.jpg)
Figure 1. Kinase fusions activate downstream cell signaling pathways such as MAP kinase signaling, JAK/STAT signaling, and PI3K/AKT1/MTOR signaling. Ultimately, the activation of downstream cell signaling pathways promotes gene transcription, cell growth, proliferation, differentiation, and survival.