Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Gene Location [1]
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type

NTRK1 Fusion is present in 0.16% of AACR GENIE cases, with sarcoma, NOS, colon adenocarcinoma, lung adenocarcinoma, thyroid gland papillary carcinoma, and gallbladder carcinoma having the greatest prevalence [4].

Top Disease Cases with NTRK1 Fusion

Biomarker-Directed Therapies

Significance of NTRK1 Fusion in Diseases

Malignant Solid Tumor +

Acute Lymphoblastic Leukemia +

Non-Small Cell Lung Carcinoma +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Melanoma +

Breast Carcinoma +

Congenital Mesoblastic Nephroma +

Head And Neck Squamous Cell Carcinoma +

Infantile Fibrosarcoma +

Lymphoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Anaplastic Large Cell Lymphoma +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndromes +

Squamous Cell Lung Carcinoma +

Malignant Colorectal Neoplasm +

Esophagogastric Carcinoma +

Malignant Glioma +

Pancreatic Carcinoma +

Central Nervous System Neoplasm +

Lung Adenocarcinoma +

Lung Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Malignant Ovarian Neoplasm +

Acute Leukemia +

Adenoid Cystic Carcinoma +

B-Cell Lymphoblastic Lymphoma +

Cervical Carcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Desmoplastic Small Round Cell Tumor +

Hematopoietic And Lymphoid Malignancy +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Lymphoblastic Lymphoma +

Mesothelioma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Multiple Myeloma +

Secondary Acute Myeloid Leukemia +

Secretory Breast Carcinoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Thymic Carcinoma +

Thymoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.