Overview

Gene Location [1]
1q23.1
Pathways
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type
Fusion
Gene
NTRK1

NTRK1 Fusion is present in 0.16% of AACR GENIE cases, with sarcoma, NOS, colon adenocarcinoma, lung adenocarcinoma, thyroid gland papillary carcinoma, and gallbladder carcinoma having the greatest prevalence [4].

Top Disease Cases with NTRK1 Fusion

Biomarker-Directed Therapies

Significance of NTRK1 Fusion in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Congenital Mesoblastic Nephroma +

Infantile Fibrosarcoma +

Lymphoma +

Non-Hodgkin Lymphoma +

Melanoma +

Colorectal Carcinoma +

Breast Carcinoma +

Anaplastic Large Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Esophagogastric Carcinoma +

Malignant Glioma +

Pancreatic Carcinoma +

Lung Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Acute Leukemia +

Acute Myeloid Leukemia +

Adenoid Cystic Carcinoma +

Cervical Carcinoma +

Hematopoietic And Lymphoid Malignancy +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mesothelioma +

Multiple Myeloma +

Secretory Breast Carcinoma +

Thymic Carcinoma +

Thymoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.