Associated Genetic Biomarkers

Overview

NCI Definition: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. [1]

Non-small cell lung carcinomas most frequently harbor alterations in TP53, KRAS, EGFR, CDKN2A, and STK11 [2].

Most Commonly Altered Genes in Non-Small Cell Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in non-small cell lung carcinoma [2].

Top Alterations in Non-Small Cell Lung Carcinoma

Significant Genes in Non-Small Cell Lung Carcinoma

ABL1 +

ABL2 +

ACVR1B +

AKT1 +

AKT2 +

AKT3 +

ALK +

APC +

ARAF +

ASS1 +

ASXL1 +

ATM +

ATR +

ATRX +

AXL +

BARD1 +

BCL2L11 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CBL +

CCND1 +

CDK12 +

CDK4 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CRKL +

CYLD +

DDR2 +

DICER1 +

DNMT3A +

EGFR +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FH +

FLT1 +

FLT3 +

FLT4 +

FRK +

GATA3 +

GRB2 +

HDAC1 +

HDAC2 +

HGF +

HRAS +

IDH1 +

IDH2 +

IRS2 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

MAGI2 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MAPK11 +

MCPH1 +

MDM2 +

MDM4 +

MED12 +

MET +

MGMT +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTAP +

MTOR +

MUTYH +

MYC +

NBN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NPM1 +

NRAS +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUTM1 +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3CG +

PIK3R1 +

PIK3R2 +

PLCG2 +

PMS1 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTCH1 +

PTEN +