Associated Genetic Biomarkers

Overview

Malignant solid tumors most frequently harbor alterations in TP53, KRAS, PIK3CA, APC, and CDKN2A [2].

Most Commonly Altered Genes in Malignant Solid Tumor

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and PIK3CA Mutation are the most common alterations in malignant solid tumor [2].

Top Alterations in Malignant Solid Tumor

Biomarker-Directed Therapies

Significant Genes in Malignant Solid Tumor

ABL1 +

ABL2 +

ACVR1B +

AFF1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

APC +

APH1A +

APOBEC3A +

APOBEC3B +

APOBEC3C +

APOBEC3D +

APOBEC3G +

APOBEC3H +

ARAF +

ARID1A +

ASXL1 +

ATM +

ATR +

ATRX +

AXL +

BAP1 +

BARD1 +

BCL2 +

BCR +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRD3 +

BRD4 +

BRIP1 +

BTRC +

C11ORF30 +

CCNA1 +

CCNA2 +

CCNB1 +

CCNB2 +

CCNB3 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDK1 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CDKN2B +

CHD4 +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

CYLD +

DAXX +

DDR2 +

DEK +

DICER1 +

DLL4 +

DNMT3A +

DVL1 +

EGFR +

ELL +

EPCAM +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC1 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

ETV6 +

EXO1 +

EZH2 +

FAM175A +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FEN1 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FH +

FIGF +

FLCN +

FLT1 +

FLT3 +

FLT4 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

GNA11 +

GNAQ +

HDAC1 +

HDAC2 +

HGF +

HRAS +

IDH1 +

IDH2 +

IRS2 +

JAG1 +

JAK1 +

JAK2 +

JAK3 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2A +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCL1 +

MCPH1 +

MDM2 +

MDM4 +

MECOM +

MED12 +

MERTK +

MET +

MLF1 +

MLH1 +

MLH3 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTAP +

MTOR +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NF2 +

NFE2L2 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

NRG1 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

NUTM1 +

PALB2 +

PARP1 +

PARP2 +

PBX1 +

PCNA +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

POLD1 +

POLE +

POLQ +

PPM1D +

PPP2R1A +

PPP2R2A +

PRKCA +

PRKCB +

PRKCD +

PRKCE +

PRKCG +

PRKCI +

PRKCQ +

PRKCZ +

PRKDC +

PTCH1 +

PTEN +

PTPN11 +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD52 +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +