Associated Genetic Biomarkers

Overview

Biomarker-Directed Therapies

Significant Genes in Malignant Solid Tumor

ABL1 +

ABL2 +

ACBD5 +

ACVR1B +

AFAP1L2 +

AFF1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

APC +

APH1A +

APOBEC3A +

APOBEC3B +

APOBEC3C +

APOBEC3D +

APOBEC3G +

APOBEC3H +

ARAF +

ARID1A +

ASXL1 +

ATM +

ATR +

ATRX +

AXL +

BAP1 +

BARD1 +

BCL2 +

BCR +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRD3 +

BRD4 +

BRIP1 +

BTRC +

C11ORF30 +

CCDC6 +

CCNA1 +

CCNA2 +

CCNB1 +

CCNB2 +

CCNB3 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDH1 +

CDK1 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CDKN2B +

CEP43 +

CHD4 +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

CTNNB1 +

CYLD +

DAXX +

DDIT3 +

DDR2 +

DEK +

DICER1 +

DLL4 +

DNMT3A +

DVL1 +

EGFR +

ELL +

EPCAM +

ERBB2 +

ERBB3 +

ERBB4 +

ERC1 +

ERCC1 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

ETV6 +

EWSR1 +

EXO1 +

EZH2 +

FAM175A +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FH +

FIGF +

FLCN +

FLI1 +

FLT1 +

FLT3 +

FLT4 +

FOXO1 +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

GNA11 +

GNAQ +

GOLGA5 +

HDAC1 +

HDAC2 +

HGF +

HOOK3 +

HRAS +

IDH1 +

IDH2 +

INPP4A +

INPP4B +

INPP5D +

INPPL1 +

IRS2 +

JAG1 +

JAK1 +

JAK2 +

JAK3 +

KDM6A +

KDR +

KEAP1 +

KIAA1217 +

KIF5B +

KIT +

KMT2A +

KMT2C +

KMT2D +

KRAS +

LRP5 +

LRP6 +

MAGI2 +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MAPK3 +

MCL1 +

MCPH1 +

MDM2 +

MDM4 +

MECOM +

MED12 +

MERTK +

MET +

MLF1 +

MLH1 +

MLH3 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTAP +

MTOR +

MUTYH +

MYC +

MYCN +

NBN +

NCOA4 +

NCSTN +

NF1 +

NF2 +

NFE2L2 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NR4A3 +

NRAS +

NRG1 +

NRIP3 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

NUTM1 +

PALB2 +

PARP1 +

PARP2 +

PBX1 +

PCNA +

PDGFB +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3C2G +

PIK3C3 +

PIK3CA +

PIK3CB +

PIK3CD +

PIK3CG +

PIK3R1 +

PIK3R2 +

PIK3R3 +

PMS1 +

PMS2 +

POLD1 +

POLE +

POLQ +

PPFIBP2 +

PPM1D +

PPP2R1A +

PPP2R2A +

PRKAR1A +

PRKCA +

PRKCB +

PRKCD +

PRKCE +

PRKCG +

PRKCI +

PRKCQ +

PRKCZ +

PRKDC +

PTCH1 +

PTEN +

PTPN11 +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RASA1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

RHEB +

RICTOR +

RNF43 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RPN1 +

RPTOR +

RSPO1 +

RUFY1 +

RUNX1 +

SDHA +

SDHAF2 +

SDHB +

SDHC +

SDHD +

SETD2 +

SLX4 +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SMO +

SOS1 +

SOX9 +

SRC +

SS18 +

SSBP1 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

STAG2 +

STAT1 +

STAT2 +

STAT3 +

STAT4 +

STAT5A +

STAT5B +

STAT6 +

STK11 +

TAF1 +

TBX3 +

TCF3 +

TEK +

TET2 +

TFE3 +

TFEB +

TFG +

TP53 +

TRIM27 +

TSC1 +

TSC2 +

TYRO3 +

UGT1A1 +

VEGFA +

VEGFB +

VEGFC +

VHL +

WNT1 +

WRN +

WT1 +

XPO1 +

XRCC1 +

XRCC2 +

Disease Details

Parent(s)
Solid Neoplasm
Children
Malignant Thoracic Neoplasm, Malignant Nervous System Neoplasm, Malignant Peritoneal Neoplasm, Hemangioblastoma, Malignant Lipomatous Neoplasm, Rhabdoid Tumor, Carcinoma, Malignant Head and Neck Neoplasm, Metastatic Malignant Neoplasm, Malignant Mesothelioma, Malignant Urinary System Neoplasm, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Malignant Fibrohistiocytic Neoplasm, Malignant Thyroid Gland Neoplasm, Malignant Skin Neoplasm, Malignant Soft Tissue Neoplasm, Malignant Giant Cell Neoplasm, Malignant Connective and Soft Tissue Neoplasm, Blastoma, Malignant Retroperitoneal Neoplasm, Choriocarcinoma, Malignant Mixed Neoplasm, Sarcoma, Malignant Digestive System Neoplasm, Malignant Breast Neoplasm, Melanoma, Malignant Endocrine Neoplasm, Malignant Reproductive System Neoplasm, Malignant Solitary Fibrous Tumor, Neuroepithelial Neoplasm, Malignant Germ Cell Tumor, Malignant Respiratory System Neoplasm, Malignant Sensory System Neoplasm, and Malignant Cardiovascular Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.