Associated Genetic Biomarkers

Overview

Malignant solid tumors most frequently harbor alterations in BRAF, NRAS, TP53, CDKN2A, and ERBB4 [2].

Most Commonly Altered Genes in Malignant Solid Tumor

BRAF Mutation, BRAF Codon 600 Missense, BRAF V600E, NRAS Mutation (somatic), and NRAS Mutation (germline) are the most common alterations in malignant solid tumor [2].

Top Alterations in Malignant Solid Tumor

Biomarker-Directed Therapies

Significant Genes in Malignant Solid Tumor

ABL1 +

ABL2 +

ACVR1B +

AFF1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

APC +

APH1A +

APOBEC3A +

APOBEC3B +

APOBEC3C +

APOBEC3D +

APOBEC3G +

APOBEC3H +

ARAF +

ARID1A +

ASXL1 +

ATM +

ATR +

ATRX +

AXL +

BAP1 +

BARD1 +

BCL2 +

BCR +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

BTRC +

C11ORF30 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CD274 +

CDK12 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CDKN2B +

CHD4 +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

CYLD +

DDR2 +

DEK +

DICER1 +

DLL4 +

DNMT3A +

DVL1 +

EGFR +

ELL +

EPHA2 +

ERBB2 +

ERBB3 +

ERBB4 +

ERCC1 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EZH2 +

FAM175A +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FEN1 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FH +

FLCN +

FLT1 +

FLT3 +

FLT4 +

FRS2 +

FYN +

FZD1 +

FZD10 +

FZD2 +

FZD3 +

FZD4 +

FZD5 +

FZD6 +

FZD7 +

FZD8 +

FZD9 +

GATA3 +

GNA11 +

GNAQ +

GRB2 +

HDAC1 +

HDAC2 +

HGF +

HRAS +

IDH1 +

IDH2 +

IRS2 +

JAG1 +

JAK1 +

JAK2 +

JAK3 +

KDM6A +

KDR +

KEAP1 +

KIAA1549 +

KIT +

KLB +

KMT2A +

KMT2D +

KRAS +

LCK +

LRP5 +

LRP6 +

LYN +

MAGI2 +

MAML1 +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCL1 +

MCPH1 +

MDM2 +

MDM4 +

MECOM +

MED12 +

MET +

MGMT +

MLF1 +

MLH1 +

MLH3 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTAP +

MTOR +

MUTYH +

MYC +

MYCN +

NBN +

NCSTN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NPM1 +

NRAS +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

NUTM1 +

PALB2 +

PARP1 +

PARP2 +

PBX1 +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +