Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
17p13.1
Pathway
Cell cycle control
Synonyms [1]
LFS1, BCC7, P53, BMFS5, TRP53

Tumor protein p53 (TP53) is a gene that codes for a tumor suppressor protein, cellular tumor antigen p53. The protein regulates expression of genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and changes in metabolism (Gene 2014). In cancer, TP53's normal roles are not fulfilled, leading to cell survival, DNA damage, and cell proliferation. TP53 is the most frequently mutated gene in cancer; it is mutated in about half of all cancers (Genetics Home Reference 2014). TP53 is most frequently mutated in ovarian, colon, and esophageal cancers, although it is significantly mutated in many other cancer types (COSMIC).

Biomarker-Directed Therapies

Significance of TP53 in Diseases

Chronic Lymphocytic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Hodgkin Lymphoma +

Multiple Myeloma +

Chronic Myelomonocytic Leukemia +

Non-Hodgkin Lymphoma +

Malignant Solid Tumor +

Acute Biphenotypic Leukemia +

Mantle Cell Lymphoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Medulloblastoma +

Non-Small Cell Lung Carcinoma +

Lymphoma +

Burkitt Lymphoma +

Acute Leukemia +

Anaplastic Large Cell Lymphoma +

Follicular Lymphoma +

Juvenile Myelomonocytic Leukemia +

Myelodysplastic/Myeloproliferative Neoplasm +

Myeloproliferative Neoplasm +

Ovarian Carcinoma +

Breast Carcinoma +

Marginal Zone Lymphoma +

Myelofibrosis +

Small Lymphocytic Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Colorectal Carcinoma +

Diffuse Large B-Cell Lymphoma +

Prolymphocytic Leukemia +

Prostate Carcinoma +

Refractory Anemia With Excess Blasts +

Secondary Acute Myeloid Leukemia +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Double-Hit Lymphoma +

Glioblastoma +

Medulloblastoma, Non-WNT/Non-SHH +

Mixed Phenotype Acute Leukemia +

Plasma Cell Leukemia +

Anaplastic Astrocytoma +

B-Cell Non-Hodgkin Lymphoma +

Bladder Carcinoma +

Endometrial Serous Adenocarcinoma +

Fallopian Tube Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

Medulloblastoma, WNT-Activated +

Myelodysplastic Syndrome With Excess Blasts-2 +

Primary Peritoneal Carcinoma +

Small Cell Lung Carcinoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Acute Undifferentiated Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Burkitt Leukemia +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Colorectal Adenocarcinoma +

Desmoplastic/Nodular Medulloblastoma +

Esophageal Squamous Cell Carcinoma +

High Grade Fallopian Tube Serous Adenocarcinoma +

Large Cell/Anaplastic Medulloblastoma +

Leukemia +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Neoplasm +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloepithelioma +

Myeloid Neoplasm +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Peripheral T-Cell Lymphoma +

Primary Peritoneal Serous Adenocarcinoma +

Refractory Anemia +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +

Acute Bilineal Leukemia +

Acute Erythroid Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Acute Megakaryoblastic Leukemia +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Acute Promyelocytic Leukemia +

Adult Acute Lymphoblastic Leukemia +

Adult T-Cell Leukemia/Lymphoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligoastrocytoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Aplastic Anemia +

Atypical Teratoid/Rhabdoid Tumor +

B-Cell Prolymphocytic Leukemia +

Breast Lobular Carcinoma In Situ +

Cancer +

Cervical Carcinoma +

Cholangiocarcinoma +

Chronic Myelomonocytic Leukemia-0 +

Chronic Myelomonocytic Leukemia-1 +

Chronic Myelomonocytic Leukemia-2 +

Clear Cell Renal Cell Carcinoma +

Desmoplastic Small Round Cell Tumor +

Diffuse Glioma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Endometrial Carcinoma +

Ependymoma +

Ependymoma, RELA Fusion-Positive +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Ewing Sarcoma +

Fallopian Tube Endometrioid Adenocarcinoma +

Gastric Carcinoma +

Gastric Squamous Cell Carcinoma +

Gastrointestinal Stromal Tumor +

Gliosarcoma +

Head And Neck Carcinoma +

Hereditary Breast And Ovarian Cancer Syndrome +

High-Grade Glioma, NOS +

Histiocytic And Dendritic Cell Neoplasm +

Indolent Non-Hodgkin Lymphoma +

Intracranial Primitive Neuroectodermal Neoplasm +

Kidney Carcinoma +

Lung Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Glioma +

Malignant Intestinal Neoplasm +

Malignant Small Intestinal Neoplasm +

Malignant Testicular Neoplasm +

Mature B-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Melanoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloid Sarcoma +

Neuroblastoma +

Ovarian Endometrioid Adenocarcinoma +

Ovarian Serous Tumor +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Pineoblastoma +

Plasma Cell Neoplasm +

Polycythemia Vera +

Primary Myelofibrosis +

Primary Peritoneal Endometrioid Adenocarcinoma +

Prostate Adenocarcinoma +

Rhabdomyosarcoma +

Sarcoma +

Secondary Myelodysplastic Syndrome +

Small Lymphocytic Leukemia +

Smoldering Plasma Cell Myeloma +

Soft Tissue Sarcoma +

T-Cell Non-Hodgkin Lymphoma +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Uterine Carcinosarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

WHO Grade III Glioma +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.